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 MouseAnti-TTX(5E7) antibody 

 

产品编号hzm-0919M
英文名称TTX(5E7)
中文名称河豚毒素单克隆抗体
别    名TETRODOTOXIN;Octahydro-12-(hydroxymethyl)-2-imino-5,9:7,10a-dimethano-10aH-[1,3]dioxocino[6,5-d]pyrimidine-4,7,10,11,12-pentol  
  
产品类型药物与化合物抗体 
研究领域免疫学  药物及化合物  海洋生物  
抗体来源Mouse
克隆类型Monoclonal
克 隆 号5E7
交叉反应TTX
产品应用ELISA=1:500-1000 (石蜡切片需做抗原修复) notyettestedinotherapplications.optimaldilutions/concentrationsshouldbedeterminedbytheenduser.
分 子 量0.31927kDa
性    状LyophilizedorLiquid
浓    度1mg/ml
免 疫 原KLHconjugatedtoTTX: 
亚    型IgG
纯化方法affinitypurifiedbyProteinG
储 存 液0.01MTBS(pH7.4)with1%BSA,0.03%Proclin300and50%Glycerol.
保存条件Storeat-20°Cforoneyear.Avoidrepeatedfreeze/thawcycles.Thelyophilizedantibodyisstableatroomtemperatureforatleastonemonthandforgreaterthanayearwhenkeptat-20°C.WhenreconstitutedinsterilepH7.40.01MPBSordiluentofantibodytheantibodyisstableforatleasttwoweeksat2-4°C.
PubMedPubMed
产品介绍background:Tetrodotoxin,frequentlyabbreviatedasTTX,isapotentneurotoxinwithnoknownantidote.Therehavebeensuccessfultestsofapossibleantidoteinmice,butfurthertestsmustbecarriedouttodetermineefficacyinhumans.Fampridinehasbeenshowntoreversetetrodotoxintoxicityinanimalexperiments.Tetrodotoxinblocksactionpotentialsinnervesbybindingtothevoltage-gated,fastsodiumchannelsinnervecellmembranes,essentiallypreventinganyaffectednervecellsfromfiringbyblockingthechannelsusedintheprocess.Thebindingsiteofthistoxinislocatedattheporeopeningofthevoltage-gatedNa+channel.ItsnamederivesfromTetraodontiformes,anorderthatincludespufferfish,porcupinefish,oceansunfishormola,andtriggerfish,severalspeciesthatcarrythetoxin.Althoughtetrodotoxinwasdiscoveredinthesefishandfoundinseveralotheranimals(e.g.,blue-ringedoctopus,rough-skinnednewt,andNaticidae)itisactuallyproducedbycertainsymbioticbacteria,suchasPseudoalteromonastetraodonis,certainspeciesofPseudomonasandVibrio,aswellassomeothersthatresidewithintheseanimals.SWISS:N/ACAS:4368-28-9ImportantNote:Thisproductassuppliedisintendedforresearchuseonly,notforuseinhuman,therapeuticordiagnosticapplications

 

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