| Tested Species Reactivity | Human |
|---|---|
| Predicted Species Reactivity | Human |
| Product Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Clonality | Polyclonal |
| Host | Rabbit |
| Application | WB |
| Reconstitution and Storage | For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Replacement Item | This antibody may replace item sc-83230 from Santa Cruz Biotechnology. |
| Immunogen | The immunogen is a synthetic peptide directed towards the C-terminal region of Human C21orf2 |
| Purification | Affinity Purified |
| Predicted Homology Based on Immunogen Sequence | Human: 100% |
| Complete computational species homology data | Anti-C21orf2 (ARP45820_P050) |
| Peptide Sequence | Synthetic peptide located within the following region: DPLDSEEEATSGAQDERGLKPPSRGQFPSLSARDASSSHRGRNVLTAILL |
| Concentration | Batch dependent within range: 100 ul at 0.5 - 1 mg/ml |
| Blocking Peptide | For anti-CFAP410 (ARP45820_P050) antibody is Catalog # AAP45820 |
| Datasheets/Manuals | Printable datasheet for anti-CFAP410 (ARP45820_P050) antibody |
| Gene Symbol | CFAP410 |
|---|---|
| Official Gene Full Name | cilia and flagella associated protein 410 |
| Alias Symbols | RDMS, SMDAX, LRRC76, YF5/A2, C21orf2 |
| NCBI Gene Id | 755 |
| Protein Name | protein C21orf2; nuclear encoded mitochondrial protein C21orf2 |
| Description of Target | Four alternatively spliced transcript variants encoding four different isoforms have been found for this nuclear gene. All isoforms contain leucine-rich repeats. Three of these isoforms are mitochondrial proteins and one of them lacks the target peptide, so is not located in mitochondrion. This gene is down-regulated in Down syndrome (DS) brain, which may represent mitochondrial dysfunction in DS patients. |
| Swissprot Id | O43822-2 |
| Protein Accession # | NP_004919 |
| Nucleotide Accession # | NM_004928 |
| Protein Size (# AA) | 215 |
| Molecular Weight | 23kDa |
| Tissue Tool | Find tissues and cell lines supported by DNA array analysis to express CFAP410.  |
| RNA Seq | Find tissues and cell lines supported by RNA-seq analysis to express CFAP410.  |
| Protein Interactions | GMCL1; ATOX1; UBC; |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
- IHC Tips & Tricks
- ICC Tips & Tricks
- ELISA Tips & Tricks
- WB/IB Tips & Tricks
- IP Tips & Tricks
See our General FAQ page.
What is the species homology for "CFAP410 Antibody - C-terminal region (ARP45820_P050)"?
The tested species reactivity for this item is "Human". This antibody is predicted to have homology to "Human".
How long will it take to receive "CFAP410 Antibody - C-terminal region (ARP45820_P050)"?
This item is available "Domestic: within 1-2 days delivery | International: 1-2 days".
What buffer format is "CFAP410 Antibody - C-terminal region (ARP45820_P050)" provided in?
This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.".Additional format options may be available. For more information please contact info@avivasysbio.com.
What are other names for "CFAP410 Antibody - C-terminal region (ARP45820_P050)"?
This target may also be called "RDMS, SMDAX, LRRC76, YF5/A2, C21orf2" in publications.
What is the shipping cost for "CFAP410 Antibody - C-terminal region (ARP45820_P050)"?
The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.
What is the guarantee for "CFAP410 Antibody - C-terminal region (ARP45820_P050)"?
All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.
Can I get bulk pricing for "CFAP410 Antibody - C-terminal region (ARP45820_P050)"?
You can get bulk pricing for this item by going here.
What is the molecular weight of the protein?
The molecular weight reported by Uniprot for this item is "23kDa".Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.
What protocols are available for "CFAP410 Antibody - C-terminal region (ARP45820_P050)"?
We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.
What are positive controls for "CFAP410"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
What are negative controls for "CFAP410"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
What other proteins interact with "CFAP410"?
This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.
What biological processes are associated with "CFAP410"?
This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.
What cellular components are associated with "CFAP410"?
This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.
What protein functions are associated with "CFAP410"?
This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.
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深夜，保姆觉得无聊就想去楼下看电视。但是她看不了，因为楼下没有电视（因为孩子的父母不希望他们的孩子看太多垃圾）。她就打电话给孩子的父母，问是否可以在他们的卧室看电视，当然孩子的父母同意了。
但保姆又想要最后一个请求。
她问是否可以用毯子或者衣服盖住那小丑雕像，因为那使她感到很害怕。
电话沉默了一会。
（此时爸爸在和保姆通话）
他说：带孩子离开房间……
我们将会叫警察……我们从来没有什么小丑雕像。
那小丑很可能是一个从监狱逃出来的杀人犯。
电话里沉默了一会儿。
（正在跟保姆通话的孩子的父亲）说：带上孩子们，离开房子……我们会通知警察……我们没有一个小丑雕像……
孩子们和保姆被小丑谋杀了。
结果是，小丑是一个从监狱里逃出来的杀人犯。
如果你不在5分钟内转发这个贴子，这个小丑在凌晨3点时将会拿着刀站在你的床前。
我在这里发了，这就是恶魔般的小丑没有杀我的原因
慢性心功能不全的病因的防治
风湿性心瓣膜病在我国仍属慢性心力衰竭的常见病因。应用青霉素治疗链球菌感染，已使风湿热和风湿性心瓣膜病在发达国家基本绝迹。择期手术治疗风湿性心瓣膜病，有效地控制高血压以及积极防治冠脉病变与心肌缺血等病因治疗；消除心力衰竭的诱因如控制感染、避免体力过劳和精神应激等。可预防心力衰竭的发生。
收缩性心力衰竭的治疗
1、减轻心脏负荷包括减少体力活动和精神应激。严重者宜绝对卧床休息，在心功能逐步改善过程中，适当下床活动，以免卧床休息过久并发静脉血栓形成或肺炎。此外，应注意解除精神负担，必要时给予小量镇静剂。
2、限制钠盐摄入适当限制日常饮食中的钠盐摄入量，食盐量2～5g，忌盐腌制食物。应用利尿剂引起大量利尿时，钠盐限制不宜过严，以免发生低钠血症。
3、利尿剂的应用利尿剂通过抑制肾小管不同部位Na+重吸收，或增加肾小球Na+滤过，增进水、Na+排出，从而降低心室充盈压，减轻肺循环和（或）体循环瘀血所致临床症状，其疗效肯定，但对心力衰竭整体过程的影响（如生存率等）不明，长期应用利尿剂理论上可能产生下列不良作用：①降低心排血量，从而激活RAS，血浆肾素和醛固酮增高。②导致低钾血症。③降低糖耐量。④导致高尿酸血症。⑤导致高脂血症。⑥导致室性心律失常。目前利尿剂属治疗心力衰竭伴水、钠潴留患者的一线药物，大多与其他心力衰竭治疗药物（如地高辛、ACE抑制剂）联合应用，单纯舒张性心力衰竭者利尿剂宜慎用。
4、正性肌力药物的应用由于慢性心力衰竭患者心肌收缩性减弱，改善心肌收缩功能曾被认为是心力衰竭的首要治疗。正性肌力药物能使心室功能曲线左上移，增加每搏作功，降低心室充盈压，从而使扩大的心脏缩小。虽然在增加心肌收缩的同时也增加心肌能量消耗，但扩大的心脏缩小后，其心肌氧耗和冠脉血供分别较心脏扩大时降低和改善，心肌能量供需的不平衡因而并不加重，甚至有所减轻。正性肌力药减轻症状、改善运动耐量和心功分级的效果明显，但多中心随机对照慢性心力衰竭患者长期临床治疗试验结果表明除洋地黄外，大多具有增高病死率与室性心律失常发生率的倾向。ACEI则不仅减轻症状、改善运动耐量和心功分级的效果更显著，且能降低病死率和病残率。因而大多数临床医师选用ACEI作为与利尿剂联用，以治疗窦性心律的慢性心力衰竭患者。
西安医专附属医院 内科心血管专家杜志桢，1976年毕业于西安医科大学医疗系。2002年晋升为主任医师，从事内科心血管疾病临床工作30余年。对冠心病、心肌缺血、心绞痛及高血压病等治疗，积累了丰富的临床经验。对心脑血管相关疾病如高脂血症、心肾功能不全的治疗亦有较成熟经验。曾担任西安医学会心血管病学会委员。前列腺素E1治疗急性肾衰获市新技术项目奖(94年)。有关心血管病近10余篇论文公开发表。为东南大学《现代医学》杂志编委。
职称：主任医师
医院科室：西安医学专科学校附属医院心内科
擅长：冠心病、高血压病、心肌病、心肌炎、心力衰竭、心律失常、心肌梗塞、心肌缺血、心绞痛治疗。
治疗病名：冠心病、心梗、顽固心律失常、高血压心脏病、心衰、心绞痛、肺心病、风心病高脂血症、动脉硬化等。展开
