

This product is freeze dried. All water molecules have been removed.

This antibody is shipped with its antigen FREE of charge!
- Peptide (C)EPKVKTQWPRSADE, corresponding to amino acid residues 277-290 of mouse BAI2 (Accession Q8CGM1). Extracellular, N-terminus.
- Western blot analysis of rat (lanes 1 and 3) and mouse (lanes 2 and 4) brain membranes:1,2. Anti-BAI2 (extracellular) Antibody (#ABR-022), (1:200).
3,4. Anti-BAI2 (extracellular) Antibody, preincubated with the negative control antigen.Western blot analysis of human SHSY-5Y neuroblastoma cell line lysates:1. Anti-BAI2 (extracellular) Antibody (#ABR-022), (1:200).
2. Anti-BAI2 (extracellular) Antibody, preincubated with the negative control antigen.
- 1. Okajima, D. et al. (2009) J. Recept. Signal Transduct. Res. 30, 143.
- 2. Jeong, B.C. et al. (2006) FEBS Lett. 580, 669.
-
Brain-specific angiogenesis inhibitor 2 (BAI2) is a member of the adhesion G-protein coupled receptor (GPCR) family. BAI2, and other members of its family, commonly have a long N-terminal extracellular region (ECR) containing a GPCR proteolysis site (GPS) adjacent to the seven-transmembrane (7TM) domain. The long N-terminus contains common structural domains, including thrombospondin type-I repeats (TSRs), epidermal growth factor (EGF)-like, leucine-rich repeats, lectin-like, immunoglobulin (Ig), and cadherins. BAI2 is composed of 521 amino acids and is mainly expressed in neurons.
Although BAI2 is a GPCR, there are currently no reports showing evidence of any physiological ligands. Instead, BAI2 is activated by cleavage and dissociation of the ECR from its 7TM fragment, and functions as a GPCR. BAI2 is glycosylated and cleaved at the GPS by furin in the ER. The cleaved N-terminal ECR associates with the C-terminal 7TM fragment and they are translocated to the cell surface. The ECR associated with the 7TM fragment interacts with other membrane proteins or matrix proteins through the TSRs and dissociates from the 7TM fragment. The 7TM fragment which has released the associated ECR changes its conformation into the active state and activates the G protein-coupled signaling1.
BAI2 is involved in the early stages of neovascularization of cerebral cortex after ischemia. Decreased levels of BAI2 induce increased VEGF expression mediated by GA-binding protein gamma (GABPγ) in cerebral ischemia and under normal conditions2.
Anti-BAI2 (extracellular) Antibody (#ABR-022) is a highly specific antibody directed against an epitope of the mouse protein. The antibody can be used in western blot analysis. The antibody recognizes an extracellular epitope, and can potentially be used for detecting the protein in living cells. It has been designed to recognize BAI2 from rat, mouse, and human samples.
ebiomall.com






>
>
>
>
>
>
>
>
>
>
>
>
这三样药是能混合在一起吃?
谢谢。
深夜,保姆觉得无聊就想去楼下看电视。但是她看不了,因为楼下没有电视(因为孩子的父母不希望他们的孩子看太多垃圾)。她就打电话给孩子的父母,问是否可以在他们的卧室看电视,当然孩子的父母同意了。
但保姆又想要最后一个请求。
她问是否可以用毯子或者衣服盖住那小丑雕像,因为那使她感到很害怕。
电话沉默了一会。
(此时爸爸在和保姆通话)
他说:带孩子离开房间……
我们将会叫警察……我们从来没有什么小丑雕像。
那小丑很可能是一个从监狱逃出来的杀人犯。
电话里沉默了一会儿。
(正在跟保姆通话的孩子的父亲)说:带上孩子们,离开房子……我们会通知警察……我们没有一个小丑雕像……
孩子们和保姆被小丑谋杀了。
结果是,小丑是一个从监狱里逃出来的杀人犯。
如果你不在5分钟内转发这个贴子,这个小丑在凌晨3点时将会拿着刀站在你的床前。
我在这里发了,这就是恶魔般的小丑没有杀我的原因

