
- SynonymIntegrin alpha 4 beta 7,ITGA4&ITGB7
- SourceBiotinylated Human ITGA4&ITGB7 Heterodimer Protein, His,Avitag&Tag Free (IT7-H82W9) is expressed from human 293 cells (HEK293). It contains AA Tyr 34 - Thr 977 (ITGA4) & Glu 20 - His 723 (ITGB7) (Accession # P13612-1 (ITGA4) & P26010-1 (ITGB7)).Predicted N-terminus: Tyr 34 & Ser 592 (ITGA4) & Glu 20 (ITGB7)
- Molecular Characterization
Biotinylated Human ITGA4&ITGB7 Heterodimer Protein, His,Avitag&Tag Free, produced by co-expression of ITGA4 and ITGB7, has a calculated MW of 113.2 kDa (ITGA4) and 81.8 kDa (ITGB7). Subunit ITGA4 is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and an Avi tag (Avitag™) and subunit ITGB7 contains no tag but a basic tail at the C-terminus. The ITGA4 subunit is composed of a heavy chain (Tyr 34 - Arg 591, calculated MW 61.1 kDa) and a light chain (Ser 592 - Thr 977, calculated MW 52.1 kDa).
- BiotinylationBiotinylation of this product is performed using Avitag™ technology. Briefly, the single lysine residue in the Avitag is enzymatically labeled with biotin.
- Endotoxin
- Formulation
Please contact us for detailed information.
Contact us for customized product form or formulation.
- Reconstitution
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
- Storage
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
- -20°C to -70°C for 12 months in lyophilized state;
- -70°C for 3 months under sterile conditions after reconstitution.
- BackgroundIntegrin alpha 4 beta 7 is an integrin family adhesion receptor that shares subunits with alpha 4 beta 1 (VLA4) and the E-Cadherin receptor, alpha E beta 7 . Integrin alpha 4 beta 7, which is critical for homing to intestinal mucosa, is induced during T cell activation in Peyer’s patches or mesenteric lymph nodes.Its expression requires signals from local dendritic and stromal cells, including secreted retinoic acid. The HIV-1 envelope protein gp120 binds to the active form of Integrin alpha 4 beta 7, and this may or may not account for the concentration of HIV-1 virus in the gut-associated lymphoid tissue (GALT). Integrinalpha 4 beta 7 may also be involved in lymphocyte trafficking in acute intestinal graft vs. host disease (GVHD).
- References
- (1)Arthos Jet, et al., 2008, Nat Immunol., 9(3), 301-9.
- (2)Monteiro P, et al., 2011, J Immunol.l., 186(8), 4618-30.
- (3)Chen YB, et al., 2013, Bone Marrow Transplant., 48(4), 598-603.
Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.
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所以说,感染同一种病毒,每个人识别的表位可能不一样。
1、存在于细胞外环境时,不显复制活性,但保持感染活性,是病毒体或病毒颗粒形式。
2、抗原,是指能够刺激机体产生(特异性)免疫应答,并能与免疫应答产物抗体和致敏淋巴细胞在体外结合,发生免疫效应(特异性反应)的物质
核心抗原由183个或185个氨基酸组成,高度磷酸化,是乙肝病毒核心颗粒的唯一结构蛋白。正由于它存在于Dane颗粒核心结构表面,被表面抗原覆盖,故不易在血循环中检出。核心抗原具有强免疫原性,可诱导很强的体液免疫和细胞免疫,刺激机体产生抗-HBc。
e抗原为可溶性蛋白质,传染性强,游离存在于血液中,虽然很早就被发现,在病理上认为是HBV复制以具有强感染性的一个指标,但其功能尚不清楚。抗-HBe的出现,是预后良好的征象。向左转|向右转
1.在手机上下载360手机卫士。
2.下载完成手机卫士之后,在手机中安装360手机卫士。在手机中打开360手机卫士并授予手机卫士 Root 权限,如图所示。
3.在手机卫士主界面打开“应用工具”选项,进入后找到“一键 Root 工具”并打开。如果手机已经获取 Root 权限,手机卫士会提示已经手机获取 Root 权限,可以解除 Root 了。
4.点击“解除 Root”按钮之后,360 Root 工具就会给出提示,“注意!解除 Root 之后将永久失去 Root 权限,并且可能无法重新获取!因此若非送修等特殊需要,不建议解除......”确认后点击“解除 Root”按钮即可解除 Root 权限。
方法二:恢复手机的出厂设置。
1.在待机页面下,点击【应用程序】。
2.点击【设定】。
3.向上滑动手机屏幕,点击【重置】。
4.点击【恢复出厂设定】。
5.点击【重置设备】。
6.点击【全部删除】。
7.完成操作后,待手机自动重启后,手机就成功恢复出厂设定了。
主要是中度以上细胞免疫缺陷包括:CD4+T淋巴细胞耗竭,外周血淋巴细胞显著减少,CD4<200/μl,CD4/CD8<1.0,(正常人为1.25~2.1),迟发型变态反应皮试阴性,有丝分裂原刺激反应低下。NK细胞活性下降。
2.各种致病性感染的病原体检查
如用PCR方法检测相关病原体,恶性肿瘤的组织病理学检查。
3.HIV抗体检测
采用酶联免疫吸附法、明胶颗粒凝集试验、免疫荧光检测法、免疫印迹检测法、放射免疫沉淀法等,其中前三项常用于筛选试验,后二者用于确证试验。
4.PCR技术检测HIV病毒。

