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Description:Inhibitorofhumantelomeraseactivity
ChemicalName:(3aS,6E,10E,11aR)-3a,4,5,8,9,11a-Hexahydro-6,10-dimethyl-3-methylene-cyclodeca[b]furan-2(3H)-one
Purity:≥97%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
Inhibitorofhumantelomeraseactivity(IC50=65μMinMCF-7breastcancercells).Suppressesproliferationandinducesapoptosisinavarietyofhumantumorcelllines.SelectivelyblocksendothelialcellproliferationinducedbyVEGF.InhibitsexpressionofiNOSandIL-1βanddisruptsNF-κBactivation.Displaysanti-inflammatory,antifungalandantiviralproperties.
TechnicalData
M.Wt | 232.32 |
Formula | C15H20O2 |
Storage | Storeat-20°C |
Purity | ≥97%(HPLC) |
CASNumber | 553-21-9 |
PubChemID | 5281437 |
InChIKey | HRYLQFBHBWLLLL-AHNJNIBGSA-N |
Smiles | C/C1=C[C@@H](OC([C@]2=C)=O)[C@H]2CC/C(C)=C/CC1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 11.62 | 50 | |
ethanol | 11.62 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight232.32.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 4.3mL | 21.52mL | 43.04mL |
5mM | 0.86mL | 4.3mL | 8.61mL |
10mM | 0.43mL | 2.15mL | 4.3mL |
50mM | 0.09mL | 0.43mL | 0.86mL |
MolarityCalculator
MolarityCalculator
Calculatethemass,volume,orconcentrationrequiredforasolution.
ReconstitutionCalculator
ReconstitutionCalculator
DilutionCalculator
DilutionCalculator
Calculatethedilutionrequiredtoprepareastocksolution.
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet


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