Tocris产品促销 Tocris Bioscience报价单,Tocris/JW 55/4514/50/50 mg,DNA聚合酶,核酸酶类,分子类,,Tocris Bioscience蚂蚁淘商城

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Tocris/JW 55/4514/50/50 mg

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Tocris

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4514/50

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4000-520-616

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Description:Tankyraseinhibitor

ChemicalName:N-[4-[[[[Tetrahydro-4-(4-methoxyphenyl)-2H-pyran-4-yl]methyl]amino]carbonyl]phenyl]-2-furancarboxamide

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

InhibitorofthePARPdomainoftankyrase1and2(TNKS1/2).ActivityresultsinstABIlizationofAxin2andincreaseddegradationofβ-catenin;inhibitstheβ-cateninsignalingpathway.AlsoshowntodecreasecanonicalWntsignalinginSW480andHCT-15coloncarcinomacelllines;reducescellcycleprogressionandproliferationinSW480cellsinvitro.

ExternalPortalInformation

Chemicalprobes.orgisaportalthatoffersindependentguidanceontheselectionand/orapplicationofsmallmoleculesforresearch.TheuseofJW55isreviewedonthechemicalprobeswebsite.

CompoundLibraries

JW55isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	434.48
Formula	C₂₅H₂₆N₂O₅
Storage	Storeat+4°C
Purity	≥98%(HPLC)
CASNumber	664993-53-7
PubChemID	2946601
InChIKey	ZJZWZIXSGNFWQQ-UHFFFAOYSA-N
Smiles	O=C(NCC2(C3=CC=C(OC)C=C3)CCOCC2)C1=CC=C(NC(C4=CC=CO4)=O)C=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	43.45	100
	ethanol	43.45	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight434.48.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.3mL	11.51mL	23.02mL
5mM	0.46mL	2.3mL	4.6mL
10mM	0.23mL	1.15mL	2.3mL
50mM	0.05mL	0.23mL	0.46mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

SafetyDatasheet

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