Tocris中国试剂购买网站进口Tocris Bioscience现货,Tocris/Triptolide/3253/10/10 mg,DNA聚合酶,Tocris,Bio-Techne,,10 mg蚂蚁淘商城

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Tocris/Triptolide/3253/10/10 mg

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3253/10

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4000-520-616

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Description:InhibitsRNAPII-mediatedtranscription;antitumor,anti-inflammatoryandimmunosuppressive

ChemicalName:(3bS,4aS,5aS,6R,6aR,7aS,7bS,8aS,8bS)-3b,4,4a,6,6a,7a,7b,8b,9,10-Decahydro-6-hydroxy-8b-methyl-6a-(1-methylethyl)trisoxireno[4b,5:6,7:8a,9]phenanthro[1,2-c]furan-1(3H)-one

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

InhibitsDNA-dependentATPaseactivityofXBPandinducesinhibitionofRNApolymeraseII(RNAPII)-mediatedtranscription(IC₅₀=200nM).SelectiveforRNAPIIoverRNAPIandRNAPIII.BlocksRNAsynthesisinHeLacells(IC₅₀=62nM);exhibitspotentantiproliferativeactivityin60cancercelllines(averageIC₅₀=12nM)andinducesapoptosisbyblockingTNF-α-mediatedc-IAP1andc-IAP2induction.Alsodisplaysimmunosuppressiveandanti-inflammatoryactivity.

CompoundLibraries

TriptolideisalsoofferedaspartoftheTocriscreenPlusandTocriscreenEpigeneticsToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	360.4
Formula	C₂₀H₂₄O₆
Storage	Storeat-20°C
Purity	≥98%(HPLC)
CASNumber	38748-32-2
PubChemID	107985
InChIKey	DFBIRQPKNDILPW-CIVMWXNOSA-N
Smiles	O=C1C2=C([C@@](C[C@H]5[C@]4(O5)[C@](O6)3[C@@H]6[C@H]7[C@](C(C)C)(O7)[C@H]4O)([H])[C@]3(C)CC2)CO1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
Solubility	DMSO	7.21	20

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight360.4.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.77mL	13.87mL	27.75mL
5mM	0.55mL	2.77mL	5.55mL
10mM	0.28mL	1.39mL	2.77mL
50mM	0.06mL	0.28mL	0.55mL

ProductDatasheets

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BiologicalActivity

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