BiologicalActivity
Cdc20inhibitor;inhibitsCdc20-substrateinteraction.Blockssubstrate-mediatedCdc20loADIngontotheanaphase-promotingcomplex(APC).InhibitsAPC-dependentubiquitylation.ProlongsmitoticdurationinRPE1cellsincombinationwithproTAME(prodrugofTAME(Cat.No.4506))invitro.
TechnicalData
| M.Wt | 438.65 |
| Formula | C13H14Cl3N7O4 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 300815-04-7 |
| PubChemID | 2830389 |
| InChIKey | ZEXHXVOGJFGTRX-UHFFFAOYSA-N |
| Smiles | CC1=NC=C([N+]([O-])=O)N1CCOC(NC(C(Cl)(Cl)Cl)NC2=NC=CC=N2)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 43.87 | 100 | |
| ethanol | 2.19 | 5mMwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight438.65.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.28mL | 11.4mL | 22.8mL |
| 5mM | 0.46mL | 2.28mL | 4.56mL |
| 10mM | 0.23mL | 1.14mL | 2.28mL |
| 50mM | 0.05mL | 0.23mL | 0.46mL |
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