Tocris公司代理生物计划 TOCRIS 4372-10MG,Tocris/Nutlin 3a/6075/25/25 mg,连接酶,核酸酶类,分子类,,Tocris Bioscience蚂蚁淘商城

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Tocris/Nutlin 3a/6075/25/25 mg

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Tocris

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6075/25

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4000-520-616

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Description:MDM2antagoNIST;activeenantiomerofNutlin-3(Cat.No.3984)

ChemicalName:4-[[(4S,5R)-4,5-Bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-piperazinone

Purity:≥97%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

MDM2antagonist(IC₅₀=90nM);inhibitstheMDM2-p53interaction.ActiveenantiomerofNutlin-3(Cat.No.3984).InducesexpressionforP53regulatedgenes.Suppressestumorgrowthinvivo>98%inprostatecancerandosteosarcomacancermodels.Antiproliferative.

TechnicalData

M.Wt	581.49
Formula	C₃₀H₃₀Cl₂N₄O₄
Storage	Storeat-20°C
Purity	≥97%(HPLC)
CASNumber	675576-98-4
PubChemID	11433190
InChIKey	BDUHCSBCVGXTJM-WUFINQPMSA-N
Smiles	ClC1=CC=C([C@H]2[C@H](N(C(N3CC(NCC3)=O)=O)C(C4=CC=C(OC)C=C4OC(C)C)=N2)C5=CC=C(Cl)C=C5)C=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	58.15	100
	ethanol	58.15	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight581.49.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	1.72mL	8.6mL	17.2mL
5mM	0.34mL	1.72mL	3.44mL
10mM	0.17mL	0.86mL	1.72mL
50mM	0.03mL	0.17mL	0.34mL

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