BiologicalActivity
HighaffinityMDM2inhibitor(Ki=28nM);directlybindsMDM2.InhibitsMDM2expressionandinducesMDM2autoubiquitinationandproteasomaldegradation.Attenuatesgrowthofbreastcancerxenografttumors.Cellpermeable.
CompoundLibraries
SP141isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 324.38 |
| Formula | C22H16N2O |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 1253491-42-7 |
| PubChemID | 59620153 |
| InChIKey | AABFWJDLCCDJJN-UHFFFAOYSA-N |
| Smiles | COC1=CC=C(NC2=C3C=CN=C2C4=CC=CC5=C4C=CC=C5)C3=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 32.44 | 100 | |
| ethanol | 32.44 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight324.38.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.08mL | 15.41mL | 30.83mL |
| 5mM | 0.62mL | 3.08mL | 6.17mL |
| 10mM | 0.31mL | 1.54mL | 3.08mL |
| 50mM | 0.06mL | 0.31mL | 0.62mL |
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