BiologicalActivity
p53activatorthatprotectsagainstMDM2-mediatedp53degradation.Elevateslevelsofp53andp21CIP/WAF1andinducesexpressionfromanendogenousp53-dependentpromoter.Exhibitspotentantiproliferativeactivityinvitro.
CompoundLibraries
Tenovin-1isalsoofferedaspartoftheTocriscreenPlusandTocriscreenEpigeneticsToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 369.48 |
| Formula | C20H23N3O2S |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 380315-80-0 |
| PubChemID | 1013376 |
| InChIKey | WOWJIWFCOPZFGV-UHFFFAOYSA-N |
| Smiles | CC(C)(C)C1=CC=C(C(NC(NC2=CC=C(NC(C)=O)C=C2)=S)=O)C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 9.24 | 25 | |
| ethanol | 1.85 | 5 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight369.48.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.71mL | 13.53mL | 27.07mL |
| 5mM | 0.54mL | 2.71mL | 5.41mL |
| 10mM | 0.27mL | 1.35mL | 2.71mL |
| 50mM | 0.05mL | 0.27mL | 0.54mL |
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