BiologicalActivity
HIF-prolylhydroxylase-2(PHD2)inhibitor.BlocksglutamateinducedROSproductioninHT-22cells,independentofMnSOD.Exhibitsneuroprotectiveeffectsandenhancesfunctionalrecoveryinrodentintracerebralhemorrhagemodels,viainhibitionofATF4dependentgenes.Brainpenetrant.Alsoantioxidant.
TechnicalData
| M.Wt | 377.82 |
| Formula | C21H16ClN3O2 |
| Storage | Storeat-20°C |
| Purity | ≥97%(HPLC) |
| CASNumber | 385786-48-1 |
| PubChemID | 3740671 |
| InChIKey | KKYHNYRUBSYTCZ-UHFFFAOYSA-N |
| Smiles | OC1=C(N=CC=C1)NC(C2=C(C3=C(C=C2)C=CC=N3)O)C4=CC=C(C=C4)Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 37.78 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight377.82.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.65mL | 13.23mL | 26.47mL |
| 5mM | 0.53mL | 2.65mL | 5.29mL |
| 10mM | 0.26mL | 1.32mL | 2.65mL |
| 50mM | 0.05mL | 0.26mL | 0.53mL |
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