BiologicalActivity
SelectiveinhibitorofTANK-bindingkinase1(TBK1)andIKKε(IC50valuesare~1-2μM).DisplaysnoeffectonIKKαorIKKβattheseconcentrations.ReversIBLylowersweight,increasesinsulinsensitivity,andreducesinflammationandsteatosisinthreemousemodelsofobesity.Exhibitsantiallergicactivity;inhibitsthereleaseofhistaminefromratmastcells.AlsobindstoHsp90andinhibitsC-terminalchaperoneactivityinvitro.
CompoundLibraries
AmlexanoxisalsoofferedaspartoftheTocriscreenPlus,TocriscreenKinaseInhibitorToolboxIIandTocriscreenLibraryofFDA-ApprovedCompounds.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 298.29 |
| Formula | C16H14N2O4 |
| Storage | Storeat-20°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 68302-57-8 |
| PubChemID | 2161 |
| InChIKey | SGRYPYWGNKJSDL-UHFFFAOYSA-N |
| Smiles | CC(C)C1=CC=C2C(C(C(C=C(C(O)=O)C(N)=N3)=C3O2)=O)=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 29.83 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight298.29.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.35mL | 16.76mL | 33.52mL |
| 5mM | 0.67mL | 3.35mL | 6.7mL |
| 10mM | 0.34mL | 1.68mL | 3.35mL |
| 50mM | 0.07mL | 0.34mL | 0.67mL |
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