正品Tocris生物试剂1 Tocris Bioscience型号参数规格,Tocris/Apicidin/4846/1/1 mg,其它酶,酶,蛋白类,,Tocris Bioscience蚂蚁淘商城

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Tocris/Apicidin/4846/1/1 mg

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Tocris

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4846/1

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4000-520-616

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Description:Potenthistonedeacetylaseinhibitor

ChemicalName:Cyclo[(2S)-2-Amino-8-oxodecanoyl-1-methoxy-L-tryptophyl-L-isoleucyl-(2R)-2-piperidinecarbonyl]

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Potenthistonedeacetylase(HDAC)inhibitor(IC₅₀=0.7nMinanenzymeactivityassay).Antiangiogenicandanti-invasive;blocksproliferationofhumanstomachandbreastcancercells.Inducesapoptosisandautophagyinhumanoralsquamouscarcinomacells.

TechnicalData

M.Wt	623.78
Formula	C₃₄H₄₉N₅O₆
Storage	Storeat-20°C
Purity	≥98%(HPLC)
CASNumber	183506-66-3
PubChemID	44593387
InChIKey	JWOGUUIOCYMBPV-VWIQTCEGSA-N
Smiles	CON2C1=CC=CC=C1C(C[C@@H](C(N[C@@H]([C@H](C)CC)C3=O)=O)NC([C@H](CCCCCC(CC)=O)NC([C@]4([H])N3CCCC4)=O)=O)=C2

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	0.94	1.5
	ethanol	0.94	1.5

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight623.78.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	1.6mL	8.02mL	16.03mL
5mM	0.32mL	1.6mL	3.21mL
10mM	0.16mL	0.8mL	1.6mL
50mM	0.03mL	0.16mL	0.32mL

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BiologicalActivity

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