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Tocris/Auranofin/4600/50/50 mg
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Tocris/Auranofin/4600/50/50 mg
品牌 / 
Tocris
货号 / 
4600/50
美元价:
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4000-520-616
Description:Thioredoxinreductaseinhibitor;inducesMPT
ChemicalName:1-Thio-β-D-glucopyranosatotriethylphosphinegold-2,3,4,6-tetraacetate
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Inhibitorofthioredoxinreductase(TrxR)(IC50=20nM;Ki=4nMfortheNADPH-reducedformofhumancytosolicTrxR).ThoughttoinducethemitochondrialpermeABIlitytransitionviainhibitionofmitochondrialTrxR.Alsoexhibitsanti-inflammatoryandimmunosuppressiveactivities;inhibits5-lipoxygenaseathighconcentrationsandstimulatesLTAhydrolaseatlowconcentrations.

TechnicalData

M.Wt678.48
FormulaC20H34AuO9PS
StorageStoreatRT
CASNumber34031-32-8
PubChemID6918453
InChIKeyAUJRCFUBUPVWSZ-XTZHGVARSA-M
SmilesCCP(CC)(CC)=[Au]S[C@H]1[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](COC(C)=O)O1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO67.85100
ethanol33.9250

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight678.48.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM1.47mL7.37mL14.74mL
5mM0.29mL1.47mL2.95mL
10mM0.15mL0.74mL1.47mL
50mM0.03mL0.15mL0.29mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet