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Description:Thioredoxinreductaseinhibitor;inducesMPT
ChemicalName:1-Thio-β-D-glucopyranosatotriethylphosphinegold-2,3,4,6-tetraacetate
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
Inhibitorofthioredoxinreductase(TrxR)(IC50=20nM;Ki=4nMfortheNADPH-reducedformofhumancytosolicTrxR).ThoughttoinducethemitochondrialpermeABIlitytransitionviainhibitionofmitochondrialTrxR.Alsoexhibitsanti-inflammatoryandimmunosuppressiveactivities;inhibits5-lipoxygenaseathighconcentrationsandstimulatesLTAhydrolaseatlowconcentrations.
TechnicalData
M.Wt | 678.48 |
Formula | C20H34AuO9PS |
Storage | StoreatRT |
CASNumber | 34031-32-8 |
PubChemID | 6918453 |
InChIKey | AUJRCFUBUPVWSZ-XTZHGVARSA-M |
Smiles | CCP(CC)(CC)=[Au]S[C@H]1[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](COC(C)=O)O1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 67.85 | 100 | |
ethanol | 33.92 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight678.48.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 1.47mL | 7.37mL | 14.74mL |
5mM | 0.29mL | 1.47mL | 2.95mL |
10mM | 0.15mL | 0.74mL | 1.47mL |
50mM | 0.03mL | 0.15mL | 0.29mL |
MolarityCalculator
MolarityCalculator
Calculatethemass,volume,orconcentrationrequiredforasolution.
ReconstitutionCalculator
ReconstitutionCalculator
DilutionCalculator
DilutionCalculator
Calculatethedilutionrequiredtoprepareastocksolution.
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet


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