BiologicalActivity
Bioreductiveprodrug;activatedbyhypoxiatoyieldthetopoisomeraseIIinhibitorAQ4.Displayslittletonocytotoxicactivityagainst60tumorcelllinestestedunderoxicconditions(IC50>100μM).Exhibitsanti-tumorefficacyinvivowhencombinedwithoxiccellcytotoxins;enhancestheanti-tumoreffectofcyclophosphamide(Cat.No.4091)inamousetumormodel.
TechnicalData
| M.Wt | 517.4 |
| Formula | C22H28N4O6.2HCl |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 252979-56-9 |
| PubChemID | 72941779 |
| InChIKey | SBWCPHUXRZRTDP-UHFFFAOYSA-N |
| Smiles | OC1=CC=C(O)C2=C1C(C(C(NCC[N+]([O-])(C)C)=CC=C3NCC[N+]([O-])(C)C)=C3C2=O)=O.Cl.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 12.94 | 25 | |
| water | 25.87 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight517.4.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.93mL | 9.66mL | 19.33mL |
| 5mM | 0.39mL | 1.93mL | 3.87mL |
| 10mM | 0.19mL | 0.97mL | 1.93mL |
| 50mM | 0.04mL | 0.19mL | 0.39mL |
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