Tocris GPCR ligands Tocris离子通道调控剂,Tocris/CKD 602/5125/50/50 mg,其它酶,酶,蛋白类,,Tocris Bioscience蚂蚁淘商城

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Tocris/CKD 602/5125/50/50 mg

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Tocris

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5125/50

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4000-520-616

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Description:TopoisomeraseIinhibitor

AlternativeNames:Belotecan,Camtobell^®

ChemicalName:(4S)-4-Ethyl-4-hydroxy-11-[2-[(1-methylethyl)amino]ethyl]-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)dionephosphate

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

TopoisomeraseIinhibitor.FormsstableDNA-topoisomerasecomplexesduringDNAreplicationandinducescellcyclearrestintheG₂/Mphase.Inhibitsgrowthofarangeofcancercelllinesinvitro,aswellasofovarianandleukemiatumorsinvivo.

TechnicalData

M.Wt	531.49
Formula	C₂₅H₂₇N₃O₄.HCl
Storage	Storeat-20°C
Purity	≥98%(HPLC)
PubChemID	123773277
InChIKey	NWUOSUHZEZPOPE-UQIIZPHYSA-N
Smiles	O=C1C2=C([C@](CC)(O)C(OC2)=O)C=C3C4=NC5=CC=CC=C5C(CCNC(C)C)=C4CN31.OP(O)(O)=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	53.15	100
	water	10.63	20

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight531.49.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	1.88mL	9.41mL	18.82mL
5mM	0.38mL	1.88mL	3.76mL
10mM	0.19mL	0.94mL	1.88mL
50mM	0.04mL	0.19mL	0.38mL

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