BiologicalActivity
InhibitorofDNAtopoisomeraseIthatdisplaysantitumoractivityagainstarangeoftumortypes.Activemetaboliteavailable(SN38,Cat.No.2684).
CompoundLibraries
CPT11isalsoofferedaspartoftheTocriscreenPlusandTocriscreenLibraryofFDA-ApprovedCompounds.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 623.14 |
| Formula | C33H38N4O6.HCl |
| Storage | StoreatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 100286-90-6 |
| PubChemID | 74990 |
| InChIKey | GURKHSYORGJETM-WAQYZQTGSA-N |
| Smiles | CCC2=C4C(C(N3C4)=CC([C@](CC)(O)C(OC5)=O)=C5C3=O)=NC1=CC=C(OC(N6CCC(N7CCCCC7)CC6)=O)C=C12.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 62.31 | 100 | |
| water | 3.12 | 5mMwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight623.14.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.6mL | 8.02mL | 16.05mL |
| 5mM | 0.32mL | 1.6mL | 3.21mL |
| 10mM | 0.16mL | 0.8mL | 1.6mL |
| 50mM | 0.03mL | 0.16mL | 0.32mL |
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