BiologicalActivity
AntitumorantibioticagentthatinhibitsDNAtopoisomeraseII.DNAintercalatorthatinhibitsnucleicacidsynthesisandinducesapoptosis.Reducesintracellulartaulevels.
CompoundLibraries
DoxorubicinhydrochlorideisalsoofferedaspartoftheTocriscreenPlusandTocriscreenLibraryofFDA-ApprovedCompounds.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 579.99 |
| Formula | C27H29NO11.HCl |
| Storage | DesiccateatRT |
| Purity | ≥98%(HPLC) |
| CASNumber | 25316-40-9 |
| PubChemID | 443939 |
| InChIKey | MWWSFMDVAYGXBV-RUELKSSGSA-N |
| Smiles | OC1=C(C[C@]([C@](CO)=O)(O)C[C@@H]4O[C@@]5([H])C[C@H](N)[C@H](O)[C@H](C)O5)C4=C(O)C3=C1C(C2=CC=CC(OC)=C2C3=O)=O.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 29 | 50 | |
| water | 29 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight579.99.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.72mL | 8.62mL | 17.24mL |
| 5mM | 0.34mL | 1.72mL | 3.45mL |
| 10mM | 0.17mL | 0.86mL | 1.72mL |
| 50mM | 0.03mL | 0.17mL | 0.34mL |
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