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Description:Antitumorantibioticagent.InhibitsDNAtopoisomeraseII
AlternativeNames:Adriamycin,NSC123127
ChemicalName:10-[(3-Amino-2,3,6-trideoxy-α-L-lyxohexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-5,12-naphthacenedionehydrochloride
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
AntitumorantibioticagentthatinhibitsDNAtopoisomeraseII.DNAintercalatorthatinhibitsnucleicacidsynthesisandinducesapoptosis.Reducesintracellulartaulevels.
CompoundLibraries
DoxorubicinhydrochlorideisalsoofferedaspartoftheTocriscreenPlusandTocriscreenLibraryofFDA-ApprovedCompounds.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
M.Wt | 579.99 |
Formula | C27H29NO11.HCl |
Storage | DesiccateatRT |
Purity | ≥98%(HPLC) |
CASNumber | 25316-40-9 |
PubChemID | 443939 |
InChIKey | MWWSFMDVAYGXBV-RUELKSSGSA-N |
Smiles | OC1=C(C[C@]([C@](CO)=O)(O)C[C@@H]4O[C@@]5([H])C[C@H](N)[C@H](O)[C@H](C)O5)C4=C(O)C3=C1C(C2=CC=CC(OC)=C2C3=O)=O.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 29 | 50 | |
water | 29 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight579.99.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 1.72mL | 8.62mL | 17.24mL |
5mM | 0.34mL | 1.72mL | 3.45mL |
10mM | 0.17mL | 0.86mL | 1.72mL |
50mM | 0.03mL | 0.17mL | 0.34mL |
MolarityCalculator
MolarityCalculator
Calculatethemass,volume,orconcentrationrequiredforasolution.
ReconstitutionCalculator
ReconstitutionCalculator
DilutionCalculator
DilutionCalculator
Calculatethedilutionrequiredtoprepareastocksolution.
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet
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