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Description:Antitumorandintercalatingagent;inhibitsDNAtopoisomeraseII
ChemicalName:5,11-Dimethyl-6H-pyrido[4,3-b]carbazole
Purity:≥97%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
Naturallyoccurringplantalkaloidwithantitumoractivity.DNAintercalatingagent;blocksDNAtopoisomeraseIIactivity.Preventsp53phosphorylationinlungcancercells.
TechnicalData
M.Wt | 246.31 |
Formula | C17H14N2 |
Storage | Storeat+4°C |
Purity | ≥97%(HPLC) |
CASNumber | 519-23-3 |
PubChemID | 3213 |
InChIKey | CTSPAMFJBXKSOY-UHFFFAOYSA-N |
Smiles | CC1=C4C(C=CN=C4)=C(C)C3=C1C2=C(N3)C=CC=C2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 12.32 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight246.31.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 4.06mL | 20.3mL | 40.6mL |
5mM | 0.81mL | 4.06mL | 8.12mL |
10mM | 0.41mL | 2.03mL | 4.06mL |
50mM | 0.08mL | 0.41mL | 0.81mL |
MolarityCalculator
MolarityCalculator
Calculatethemass,volume,orconcentrationrequiredforasolution.
ReconstitutionCalculator
ReconstitutionCalculator
DilutionCalculator
DilutionCalculator
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ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet
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