生命科学Tocris价格优惠 Tocris多肽,Tocris/GSK J4/4594/50/50 mg,其它酶,酶,蛋白类,,Tocris Bioscience蚂蚁淘商城

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Tocris/GSK J4/4594/50/50 mg

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Tocris

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4594/50

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4000-520-616

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Description:HistoneKDMinhibitor;cellpermeable

ChemicalName:N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alanineethylester

Purity:≥99%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Histonelysinedemethylase(KDM)inhibitor;blocksdemethylationofhistoneH3K27.Attenuateslipopolysaccharide(LPS)-inducedproinflammatorycytokineproductioninprimaryhumanmacrophages(IC₅₀=9μMfortheinhibitionofTNFαrelease).Cellpermeable.EthylesterderivativeofGSKJ1(Cat.No.4593).

LicensingInformation

ThisprobeissuppliedinconjunctionwiththeStructuralGenomicsConsortium.ForfurthercharacterizationdetailsofGSKJ4,acellpermeablederivativeofGSKJ1,pleasevisittheGSKJ1probesummaryontheSGCwebsite.

ExternalPortalInformation

Chemicalprobes.orgisaportalthatoffersindependentguidanceontheselectionand/orapplicationofsmallmoleculesforresearch.TheuseofGSKJ4isreviewedonthechemicalprobeswebsite.

CompoundLibraries

GSKJ4isalsoofferedaspartoftheTocriscreenPlusandTocriscreenEpigeneticsToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	417.5
Formula	C₂₄H₂₇N₅O₂
Storage	StoreatRT
Purity	≥99%(HPLC)
CASNumber	1373423-53-0
PubChemID	71729975
InChIKey	WBKCKEHGXNWYMO-UHFFFAOYSA-N
Smiles	O=C(CCNC1=NC(C2=CC=CC=N2)=NC(N3CCC(C=CC=C4)=C4CC3)=C1)OCC

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	41.75	100
	ethanol	41.75	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight417.5.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.4mL	11.98mL	23.95mL
5mM	0.48mL	2.4mL	4.79mL
10mM	0.24mL	1.2mL	2.4mL
50mM	0.05mL	0.24mL	0.48mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

SafetyDatasheet

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