BiologicalActivity
Oncometaboliteproducedbymutantisocitratedehydrogenase1(IDH1)andIDH2.InhibitsKDM4AinmurineembryonicfibroblastsresultinginactivationofmTOR.AlsoactivatesNF-κBinbonemarrowstromalcells.
TechnicalData
| M.Wt | 192.08 |
| Formula | C5H6Na2O5 |
| Storage | Storeat-20°C |
| CASNumber | 103404-90-6 |
| PubChemID | 45489701 |
| InChIKey | DZHFTEDSQFPDPP-HWYNEVGZSA-L |
| Smiles | O[C@@H](C(O[Na])=O)CCC(O[Na])=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| water | 19.21 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight192.08.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 5.21mL | 26.03mL | 52.06mL |
| 5mM | 1.04mL | 5.21mL | 10.41mL |
| 10mM | 0.52mL | 2.6mL | 5.21mL |
| 50mM | 0.1mL | 0.52mL | 1.04mL |
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