BiologicalActivity
DNAtopoisomeraseIinhibitor.Exhibitsadifferentinhibitorymechanismtocamptothecin(Cat.No.1100).Inducesapoptosisinavarietyofcelllines,includingprostatecancerandpromyelocyticleukemiacells;blocksthecellcycleinG0/G1.AlsohaseffectsonDNAtopoisomeraseII,NF-κB,AP-1,andJNK.
TechnicalData
| M.Wt | 242.27 |
| Formula | C15H14O3 |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 4707-32-8 |
| PubChemID | 3885 |
| InChIKey | QZPQTZZNNJUOLS-UHFFFAOYSA-N |
| Smiles | O=C(C(C3=C2OC(C)(C)CC3)=O)C1=C2C=CC=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 24.23 | 100 | |
| ethanol | 12.11 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight242.27.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 4.13mL | 20.64mL | 41.28mL |
| 5mM | 0.83mL | 4.13mL | 8.26mL |
| 10mM | 0.41mL | 2.06mL | 4.13mL |
| 50mM | 0.08mL | 0.41mL | 0.83mL |
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