BiologicalActivity
Histonedeacetylaseinhibitor(IC50=100nM).InducesterminalcelldifferentiationandcausesanincreaseinhyperacetylatedhistoneH4.Antiproliferativeagent;suppressesthegrowthofhumanendometrialandovariancancercellsbyinducingcellcyclearrestandapoptosis.
CompoundLibraries
M344isalsoofferedaspartoftheTocriscreenPlusandTocriscreenEpigeneticsToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 307.39 |
| Formula | C16H25N3O3 |
| Storage | StoreatRT |
| Purity | ≥98%(HPLC) |
| CASNumber | 251456-60-7 |
| PubChemID | 3994 |
| InChIKey | MXWDSZWTBOCWBK-UHFFFAOYSA-N |
| Smiles | O=C(NCCCCCCC(NO)=O)C1=CC=C(N(C)C)C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 30.74 | 100 | |
| ethanol | 6.15 | 20 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight307.39.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.25mL | 16.27mL | 32.53mL |
| 5mM | 0.65mL | 3.25mL | 6.51mL |
| 10mM | 0.33mL | 1.63mL | 3.25mL |
| 50mM | 0.07mL | 0.33mL | 0.65mL |
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