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Description:Potent17β-hydroxysteroiddehydrogenasetype5inhibitor;orallybioavailable
ChemicalName:[4-(2-Hydroxy-2-methylpropyl)-1-piperidinyl](5-methoxy-1H-indol-2-yl)methanone
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
Potent17β-hydroxysteroiddehydrogenasetype5inhibitor(IC50=11-49nM).Suppressesandrostenedione-dependentprotein-specificantigen(PSA)productionandcellproliferationinLNCaPcellsinvitro.Orallybioavailable.
TechnicalData
M.Wt | 330.42 |
Formula | C19H26N2O3 |
Storage | Storeat+4°C |
Purity | ≥98%(HPLC) |
CASNumber | 1126084-37-4 |
PubChemID | 25210792 |
InChIKey | OXSCPDKUZWPWFR-UHFFFAOYSA-N |
Smiles | O=C(N1CCC(CC1)CC(C)(O)C)C2=CC3=CC(OC)=CC=C3N2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 33.04 | 100 | |
ethanol | 33.04 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight330.42.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 3.03mL | 15.13mL | 30.26mL |
5mM | 0.61mL | 3.03mL | 6.05mL |
10mM | 0.3mL | 1.51mL | 3.03mL |
50mM | 0.06mL | 0.3mL | 0.61mL |
MolarityCalculator
MolarityCalculator
Calculatethemass,volume,orconcentrationrequiredforasolution.
ReconstitutionCalculator
ReconstitutionCalculator
DilutionCalculator
DilutionCalculator
Calculatethedilutionrequiredtoprepareastocksolution.
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet
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