BiologicalActivity
PotentmicrosomalprostaglandinEsynthase1(mPGES-1)inhibitor(IC50valuesare16.5and1080nMforhumanandratmPGES-1,respectively).Exhibits>6500-foldselectivityformPGES-1overCOX-1andCOX-2.InhibitsIL-1β-inducedPGE2synthesisinvitro.
LicensingInformation
SoldforresearchpurposesunderagreementfromPfizerInc.
TechnicalData
| M.Wt | 461.32 |
| Formula | C21H14Cl2N2O4S |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 1221971-47-6 |
| PubChemID | 54728414 |
| InChIKey | VGACSWBJQLLJFB-UHFFFAOYSA-N |
| Smiles | OC2=C(C(NC3=CC=C(C4=CC=C(Cl)C(Cl)=C4)C=C3)=O)NS(C1=CC=CC=C12)(=O)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 46.13 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight461.32.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.17mL | 10.84mL | 21.68mL |
| 5mM | 0.43mL | 2.17mL | 4.34mL |
| 10mM | 0.22mL | 1.08mL | 2.17mL |
| 50mM | 0.04mL | 0.22mL | 0.43mL |
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