BiologicalActivity
Thioredoxin-1(Trx-1)inhibitor;irreversIBLyinactivatesTrx-1asasubstrateforreductionbythioredoxinreductase(TR);competitivelyinhibitsthereductionofTrx-1byTR(Ki=30.8μM).AttenuatesexpressionofHIF-1α,VEGFandiNOS(IC50valuesare7.2,10.4and18.1μMrespectively).Exhibitsantitumoractivity;directlyinhibitstubulininvitroanddecreasestumormicrovesseldensityinvivo.
TechnicalData
| M.Wt | 188.31 |
| Formula | C7H12N2S2 |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 141400-58-0 |
| PubChemID | 219104 |
| InChIKey | BPBPYQWMFCTCNG-UHFFFAOYSA-N |
| Smiles | CC(CC)SSC1=NC=CN1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 18.83 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight188.31.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 5.31mL | 26.55mL | 53.1mL |
| 5mM | 1.06mL | 5.31mL | 10.62mL |
| 10mM | 0.53mL | 2.66mL | 5.31mL |
| 50mM | 0.11mL | 0.53mL | 1.06mL |
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