BiologicalActivity
SyntheticinhibitorofHMG-CoAreductase(Ki=1.7nM).Lowerslow-densitylipoprotein(LDL)cholesterollevels.DisplaysminimalmetabolismbycytochromeP450enzymes,withlittleinvolvementofCYP3A4.Showntoimprovecardiacfunctionandsurvivalinaratmodelofhypertensiveheartfailure.
CompoundLibraries
PitavastatincalciumisalsoofferedaspartoftheTocriscreenPlusandTocriscreenLibraryofFDA-ApprovedCompounds.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 440.5 |
| Formula | C25H23FNO4.0.5Ca |
| Storage | DesiccateatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 147526-32-7 |
| PubChemID | 5282451 |
| InChIKey | RHGYHLPFVJEAOC-FFNUKLMVSA-L |
| Smiles | [Ca++].O[C@H](C[C@H](O)C=CC1=C(C2=CC=C(F)C=C2)C2=CC=CC=C2N=C1C1CC1)CC([O-])=O.O[C@H](C[C@H](O)C=CC1=C(C2=CC=C(F)C=C2)C2=CC=CC=C2N=C1C1CC1)CC([O-])=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 44.05 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight440.5.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.27mL | 11.35mL | 22.7mL |
| 5mM | 0.45mL | 2.27mL | 4.54mL |
| 10mM | 0.23mL | 1.14mL | 2.27mL |
| 50mM | 0.05mL | 0.23mL | 0.45mL |
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