BiologicalActivity
Potentandselectivedihydroorotatedehydrogenase(DHODH)inhibitor(IC50=~20nM).Causesdepletionofpyrimidinenucleotides.Exhibitsminimalinhibitionagainstapanelof>400kinases.TriggersdifferentiationofAMLcelllines(ED50=~1μM.NoteuridineconcentrationeffectsED50value).Causesdifferentiationanddepletionofleukemia-initiatingcellsinvivo.Antimetabolite.
TechnicalData
| M.Wt | 397.35 |
| Formula | C23H14F2NO2Na |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 96201-88-6 |
| PubChemID | 23663964 |
| InChIKey | PZOHOALJQOFNTB-UHFFFAOYSA-M |
| Smiles | CC1=C(C2=CC(F)=CC=C2N=C1C3=CC=C(C4=C(C=CC=C4)F)C=C3)C(O[Na])=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 39.73 | 100 | |
| water | 39.73 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight397.35.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.52mL | 12.58mL | 25.17mL |
| 5mM | 0.5mL | 2.52mL | 5.03mL |
| 10mM | 0.25mL | 1.26mL | 2.52mL |
| 50mM | 0.05mL | 0.25mL | 0.5mL |
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