BiologicalActivity
Potentandselectivelysosomalacidlipase(LAL)inhibitor(IC50=68nM).Exhibitsnosignificantactivityagainstpancreaticlipaseorlipoproteinlipaseat10μMconcentration.BlocksLAL-mediatedlipidhydrolysisofacetylatedLDLandreduceseffluxofcholesterolfromlipid-loadedcellsresultinginincreasedcellularcholesterolesterlevels.
TechnicalData
| M.Wt | 298.36 |
| Formula | C12H18N4O3S |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 501104-16-1 |
| PubChemID | 648404 |
| InChIKey | GKOPFXFKPASEFI-UHFFFAOYSA-N |
| Smiles | O=C(OC1=NSN=C1N2CCCCC2)N3CCOCC3 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 29.84 | 100 | |
| ethanol | 29.84 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight298.36.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.35mL | 16.76mL | 33.52mL |
| 5mM | 0.67mL | 3.35mL | 6.7mL |
| 10mM | 0.34mL | 1.68mL | 3.35mL |
| 50mM | 0.07mL | 0.34mL | 0.67mL |
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