BiologicalActivity
Antianginalagentwithantiarrhythmicpropertiesthatactsasapartialfattyacidoxidationinhibitor.Activatespyruvatedehydrogenaseinischemicmyocytestopromoteglucoseoxidation,switchingsubstrateutilizationfromfattyacidstoglucose.AlsoshowntoinhibitlateINaandIKrcurrents.
CompoundLibraries
RanolazinedihydrochlorideisalsoofferedaspartoftheTocriscreenPlusandTocriscreenLibraryofFDA-ApprovedCompounds.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 500.46 |
| Formula | C24H33N3O4.2HCl |
| Storage | DesiccateatRT |
| Purity | ≥98%(HPLC) |
| CASNumber | 95635-56-6 |
| PubChemID | 71279 |
| InChIKey | RJNSNFZXAZXOFX-UHFFFAOYSA-N |
| Smiles | COC1=CC=CC=C1OCC(CN2CCN(CC(NC3=C(C)C=CC=C3C)=O)CC2)O.Cl.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 50.05 | 100 | |
| water | 50.05 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight500.46.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2mL | 9.99mL | 19.98mL |
| 5mM | 0.4mL | 2mL | 4mL |
| 10mM | 0.2mL | 1mL | 2mL |
| 50mM | 0.04mL | 0.2mL | 0.4mL |
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