BiologicalActivity
Potentandcompetitivekynurenine3-monooxygenase(kynurenine3-hydroxylase;KMO)inhibitor(Ki=4.8nM,IC50=37nM).IncreaseskynurenicacidlevelstoconcentrationsthatantagonizetheglycinesiteofNMDAreceptors.Brainpenetrantandexhibitsantidystonic,anticonvulsantandneuroprotectiveactivities.
CompoundLibraries
Ro61-8048isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 421.45 |
| Formula | C17H15N3O6S2 |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 199666-03-0 |
| PubChemID | 5282337 |
| InChIKey | NDPBMCKQJOZAQX-UHFFFAOYSA-N |
| Smiles | O=S(NC1=NC(C2=CC=CC([N+]([O-])=O)=C2)=CS1)(C3=CC=C(OC)C(OC)=C3)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 42.15 | 100 | |
| ethanol | 4.21 | 10 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight421.45.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.37mL | 11.86mL | 23.73mL |
| 5mM | 0.47mL | 2.37mL | 4.75mL |
| 10mM | 0.24mL | 1.19mL | 2.37mL |
| 50mM | 0.05mL | 0.24mL | 0.47mL |
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