BiologicalActivity
ActivemetaboliteofCPT-11(Cat.No.2688)thatinhibitsDNAtopoisomeraseI(IC50valuesare0.74and1.9μMinP388andEhrlichcellsrespectively).InhibitsDNAandRNAsynthesis(IC50valuesare0.077and1.3μMrespectively)butdoesnotaffectproteinsynthesis.Displayspotentantitumoractivityagainstarangeofhumantumorcelllines(IC50valuesare3.3,13,19and22nMforHCT-116,BEL-7402,HL60andHELAcellsrespectively).
CompoundLibraries
SN38isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 392.4 |
| Formula | C22H20N2O5 |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 86639-52-3 |
| PubChemID | 104842 |
| InChIKey | FJHBVJOVLFPMQE-QFIPXVFZSA-N |
| Smiles | OC1=CC=C(N=C(C(N3C4)=CC([C@](CC)(O)C(OC5)=O)=C5C3=O)C4=C2CC)C2=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 39.24 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight392.4.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.55mL | 12.74mL | 25.48mL |
| 5mM | 0.51mL | 2.55mL | 5.1mL |
| 10mM | 0.25mL | 1.27mL | 2.55mL |
| 50mM | 0.05mL | 0.25mL | 0.51mL |
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