中国Tocris公司 Tocris小分子,Tocris/Topotecan hydrochloride/4562/10/10 mg,其它酶,酶,蛋白类,,Tocris Bioscience蚂蚁淘商城

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Tocris/Topotecan hydrochloride/4562/10/10 mg

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Tocris/Topotecan hydrochloride/4562/10/10 mg

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Tocris

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4562/10

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Description:DNAtopoisomeraseIinhibitor;Camptothecin(Cat.No.1100)analog

AlternativeNames:SK&F104864-A

ChemicalName:10-[(Dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dionehydrochloride

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

DNAtopoisomeraseIinhibitor;inducesrapidapoptoticdeathinhumanB-lineageacutelymphoblasticleukemia(ALL)cells.ImprovessurvivalinthreemousemodelsofpoorprognosisALL;downregulatesB-MybandMycNexpressioninneuroblastomacells.Water-solubleanalogofCamptothecin(Cat.No.1100).Orallybioavailable.

TechnicalData

M.Wt	457.91
Formula	C₂₃H₂₃N₃O₅.HCl
Storage	Storeat-20°C
Purity	≥98%(HPLC)
CASNumber	119413-54-6
PubChemID	60699
InChIKey	DGHHQBMTXTWTJV-BQAIUKQQSA-N
Smiles	OC1=CC=C(N=C(C(N3C4)=CC([C@](CC)(O)C(OC5)=O)=C5C3=O)C4=C2)C2=C1CN(C)C.Cl

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	45.79	100
	water	45.79	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight457.91.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.18mL	10.92mL	21.84mL
5mM	0.44mL	2.18mL	4.37mL
10mM	0.22mL	1.09mL	2.18mL
50mM	0.04mL	0.22mL	0.44mL

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