BiologicalActivity
Potentkynurenine3-monooxygenase(kynurenine3-hydroxylase;KMO)inhibitor(IC50=20nM).Increaseskynurenicacidlevels,anddecreases3-HKandQUINlevelsincerebrumandliverofneonatalrodents.NeuroprotectiveinaDrosophilamodelofHuntington'sdisease.
TechnicalData
| M.Wt | 259.09 |
| Formula | C11H8Cl2O3 |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 213400-34-1 |
| PubChemID | 9859947 |
| InChIKey | ZBRKMOHDGFGXLN-BQBZGAKWSA-N |
| Smiles | [H][C@]1([C@@H]([C@](O)=O)C1)C(C2=CC=C(Cl)C(Cl)=C2)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| ethanol | 25.91 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight259.09.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.86mL | 19.3mL | 38.6mL |
| 5mM | 0.77mL | 3.86mL | 7.72mL |
| 10mM | 0.39mL | 1.93mL | 3.86mL |
| 50mM | 0.08mL | 0.39mL | 0.77mL |
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