BiologicalActivity
Orallyactiveα-glucosidaseinhibitor(IC50valuesare3.9and6.4nMatsucraseandmaltaserespectively).Increasesglucagon-likepeptide1(GLP-1)secretionanddecreasesfoodconsumptioninob/obmice,andreducesplasmaconcentrationsofglucose,triglyceridesandinsulininWistarfattyrats.Exhibitsantidiabeticandantiobesityactivityinvivo.
CompoundLibraries
VogliboseisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 267.28 |
| Formula | C10H21NO7 |
| Storage | Storeat-20°C |
| CASNumber | 83480-29-9 |
| PubChemID | 444020 |
| InChIKey | FZNCGRZWXLXZSZ-CIQUZCHMSA-N |
| Smiles | O[C@@H]1[C@](CO)(O)C[C@H](NC(CO)CO)[C@H](O)[C@H]1O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 20.05 | 75 | |
| water | 26.73 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight267.28.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.74mL | 18.71mL | 37.41mL |
| 5mM | 0.75mL | 3.74mL | 7.48mL |
| 10mM | 0.37mL | 1.87mL | 3.74mL |
| 50mM | 0.07mL | 0.37mL | 0.75mL |
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