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Tocris/Xanthohumol/4686/10/10 mg

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Tocris

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4686/10

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4000-520-616

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Description:p97ATPase(VCP)inhibitor

ChemicalName:(2E)-1-[2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

p97ATPase(VCP)inhibitor.BindstotheNdomainofp97,impairingautophagosomefunctionandmaturation.Inhibitsproliferationandinducesapoptosisinavarietyofhumancancercelllines.AlsoinhibitsDGATinratlivermicrosomes(IC₅₀=50.3μM).

TechnicalData

M.Wt	354.4
Formula	C₂₁H₂₂O₅
Storage	Storeat+4°C
Purity	≥98%(HPLC)
CASNumber	6754-58-1
PubChemID	639665
InChIKey	ORXQGKIUCDPEAJ-YRNVUSSQSA-N
Smiles	OC1=C(C(/C=C/C2=CC=C(O)C=C2)=O)C(OC)=CC(O)=C1C/C=C(C)/C

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	35.44	100
	ethanol	35.44	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight354.4.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.82mL	14.11mL	28.22mL
5mM	0.56mL	2.82mL	5.64mL
10mM	0.28mL	1.41mL	2.82mL
50mM	0.06mL	0.28mL	0.56mL

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