进口Tocris试剂盒，血清清关中国Tocris Bioscience公司,Tocris/GSK 343/6128/50/50 mg,其它酶,酶,蛋白类,,Tocris Bioscience蚂蚁淘商城

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Tocris/GSK 343/6128/50/50 mg

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Tocris

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6128/50

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4000-520-616

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Description:PotentandselectiveSAM-competitiveEZH2inhibitor

ChemicalName:N-[(1,2-Dihydro-6-methyl-2-oxo-4-propyl-3-pyridinyl)methyl]-1-(1-methylethyl)-6-[2-(4-methyl-1-piperazinyl)-4-pyridinyl]-1H-indazole-4-carboxamide

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentandselectiveSAM-competitiveEZH2inhibitor(IC₅₀=4mM).Exhibits>60foldselectivityforEZH2overEZH1andarangeofothermethyltransferases.Inhibitsproliferationofprostatecancercelllinesinvitro.

LicensingInformation

ThisprobeissuppliedinconjunctionwiththeStructuralGenomicsConsortium.Forfurthercharacterizationdetails,pleasevisittheGSK343probesummaryontheSGCwebsite.

TechnicalData

M.Wt	541.69
Formula	C₃₁H₃₉N₇O₂
Storage	Storeat-20°C
Purity	≥98%(HPLC)
CASNumber	1346704-33-3
PubChemID	71268957
InChIKey	ULNXAWLQFZMIHX-UHFFFAOYSA-N
Smiles	CCCC1=C(C(NC(C)=C1)=O)CNC(C2=C3C=NN(C3=CC(C4=CC=NC(N5CCN(CC5)C)=C4)=C2)C(C)C)=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
Solubility	DMSO	10.83	20mMwithgentlewarming

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight541.69.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	1.85mL	9.23mL	18.46mL
5mM	0.37mL	1.85mL	3.69mL
10mM	0.18mL	0.92mL	1.85mL
50mM	0.04mL	0.18mL	0.37mL

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