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Description:PDE3/4inhibitor
ChemicalName:6-[4-(Difluoromethoxy)-3-methoxyphenyl]-3(2H)-pyridazinone
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
Phosphodiesteraseinhibitor,selectiveforPDE3and4(IC50valuesare0.5and0.8μMrespectively).AlsoavailableaspartofthePhosphodiesteraseInhibitorTocriset™.
CompoundLibraries
ZardaverineisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
M.Wt | 268.22 |
Formula | C12H10F2N2O3 |
Storage | StoreatRT |
Purity | ≥98%(HPLC) |
CASNumber | 101975-10-4 |
PubChemID | 5723 |
InChIKey | HJMQDJPMQIHLPB-UHFFFAOYSA-N |
Smiles | COC1=C(OC(F)F)C=CC(=C1)C1=NNC(=O)C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
Solubility | Solubleto100mMinDMSO |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight268.22.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 3.73mL | 18.64mL | 37.28mL |
5mM | 0.75mL | 3.73mL | 7.46mL |
10mM | 0.37mL | 1.86mL | 3.73mL |
50mM | 0.07mL | 0.37mL | 0.75mL |
MolarityCalculator
MolarityCalculator
Calculatethemass,volume,orconcentrationrequiredforasolution.
ReconstitutionCalculator
ReconstitutionCalculator
DilutionCalculator
DilutionCalculator
Calculatethedilutionrequiredtoprepareastocksolution.
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet


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