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Tocris/Zoledronic Acid/6111/10/10 mg
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Tocris/Zoledronic Acid/6111/10/10 mg
品牌 / 
Tocris
货号 / 
6111/10
美元价:
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数    量:
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4000-520-616
Description:Potentfarnesyldiphosphate(FPP)synthaseinhibitor
AlternativeNames:Zometa
ChemicalName:[1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene]bisphosphonicacid
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Potentbisphophonatefarnesyldiphosphate(FPP)synthaseinhibitor(IC50=20nM).Inhibitsosteoclast-mediatedboneresorption.AlsoinhibitsRassignalingandtumorgrowth,andinducesapoptosisinpancreaticcancercells.Reversesepithelial-mesenchymaltransitionandinhibitsbreastcancercellrenewalviainactivationofNF-κB.

TechnicalData

M.Wt272.09
FormulaC5H10N2O7P2
StorageStoreat+4°C
Purity≥98%(HPLC)
CASNumber118072-93-8
PubChemID68740
InChIKeyXRASPMIURGNCCH-UHFFFAOYSA-N
SmilesOC(P(O)(O)=O)(P(O)(O)=O)CN1C=CN=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
water0.682.5
1.1eq.NaOH13.650

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight272.09.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM3.68mL18.38mL36.75mL
5mM0.74mL3.68mL7.35mL
10mM0.37mL1.84mL3.68mL
50mM0.07mL0.37mL0.74mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet