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Description:Potentfarnesyldiphosphate(FPP)synthaseinhibitor
AlternativeNames:Zometa
ChemicalName:[1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene]bisphosphonicacid
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
Potentbisphophonatefarnesyldiphosphate(FPP)synthaseinhibitor(IC50=20nM).Inhibitsosteoclast-mediatedboneresorption.AlsoinhibitsRassignalingandtumorgrowth,andinducesapoptosisinpancreaticcancercells.Reversesepithelial-mesenchymaltransitionandinhibitsbreastcancercellrenewalviainactivationofNF-κB.
TechnicalData
M.Wt | 272.09 |
Formula | C5H10N2O7P2 |
Storage | Storeat+4°C |
Purity | ≥98%(HPLC) |
CASNumber | 118072-93-8 |
PubChemID | 68740 |
InChIKey | XRASPMIURGNCCH-UHFFFAOYSA-N |
Smiles | OC(P(O)(O)=O)(P(O)(O)=O)CN1C=CN=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
water | 0.68 | 2.5 | |
1.1eq.NaOH | 13.6 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight272.09.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 3.68mL | 18.38mL | 36.75mL |
5mM | 0.74mL | 3.68mL | 7.35mL |
10mM | 0.37mL | 1.84mL | 3.68mL |
50mM | 0.07mL | 0.37mL | 0.74mL |
MolarityCalculator
MolarityCalculator
Calculatethemass,volume,orconcentrationrequiredforasolution.
ReconstitutionCalculator
ReconstitutionCalculator
DilutionCalculator
DilutionCalculator
Calculatethedilutionrequiredtoprepareastocksolution.
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet


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