BiologicalActivity
Adenylylcyclase1(AC1)inhibitor(IC50=2.3μM).ExhibitssomeselectivityforAC1overotherACisoforms,withnosignificantactivityagainstAC8.InhibitsCa2+/calmodulin-stimulatedcAMPaccumulationinhippocampalhomogenates.Enhancesμopioidreceptor(MOR)-mediatedinhibitionofAC1incellularassaysandinhibitsdevelopmentandmaintenanceofMOR-mediatedsensitizationofAC1.Activeinvivo.Analgesic.
TechnicalData
| M.Wt | 297.95 |
| Formula | C10H4Cl4O2 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 133406-29-8 |
| PubChemID | 867466 |
| InChIKey | NTDHYMSVCBGQJF-UHFFFAOYSA-N |
| Smiles | ClC1=CC=C2OC(C(Cl)(Cl)Cl)=CC(C2=C1)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 29.8 | 100 | |
| ethanol | 5.96 | 20 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight297.95.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.36mL | 16.78mL | 33.56mL |
| 5mM | 0.67mL | 3.36mL | 6.71mL |
| 10mM | 0.34mL | 1.68mL | 3.36mL |
| 50mM | 0.07mL | 0.34mL | 0.67mL |
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