Tocris一级代理 Tocris化合物筛选文库,Tocris/AGK 2/3233/10/10 mg,其它酶,酶,蛋白类,,Tocris Bioscience蚂蚁淘商城

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Tocris/AGK 2/3233/10/10 mg

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Tocris

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3233/10

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4000-520-616

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Description:SelectiveSIRT2inhibitor

ChemicalName:2-Cyano-3-[[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

SelectiveinhibitorofSIRT2(IC₅₀=3.5μM).DisplaysnoactivityatSIRT1andSIRT3atconcentrationsupto40μM.Reducesα-synuclein-mediatedtoxicityininvitroandinvivomodelsofParkinson'sdisease.

TechnicalData

M.Wt	434.27
Formula	C₂₃H₁₃Cl₂N₃O₂
Storage	Storeat+4°C
Purity	≥98%(HPLC)
CASNumber	304896-28-4
PubChemID	2130404
InChIKey	SVENPFFEMUOOGK-SDNWHVSQSA-N
Smiles	O=C(/C(C#N)=C/C3=CC=C(C4=C(Cl)C=CC(Cl)=C4)O3)NC2=CC=CC1=NC=CC=C12

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
Solubility	DMSO	4.34	10

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight434.27.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.3mL	11.51mL	23.03mL
5mM	0.46mL	2.3mL	4.61mL
10mM	0.23mL	1.15mL	2.3mL
50mM	0.05mL	0.23mL	0.46mL

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