美国Tocris公司 Tocris BioscienceX中国代理价格，厂家,Tocris/ARRY 520 trifluoroacetate/4676/10/10 mg,其它酶,酶,蛋白类,,Tocris Bioscience蚂蚁淘商城

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Tocris/ARRY 520 trifluoroacetate/4676/10/10 mg

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Tocris/ARRY 520 trifluoroacetate/4676/10/10 mg

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Tocris

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4676/10

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4000-520-616

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Description:Potentandselectivekinesinspindleprotein(KSP)inhibitor;inducesMcl-1degradation

AlternativeNames:Filanesib

ChemicalName:(2S)-2-(3-Aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-1,3,4-thiADIazole-3(2H)-carboxamidetrifluoroacetate

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Potentkinesinspindleprotein(KSP)inhibitor(IC₅₀=6nM);selectiveforKSPover>250otherreceptorsandkinasesataconcentrationof10μM.Displaysrobustantitumoractivityinbortezomib-resistantxenograftseitheraloneorincombinationwithbortezomib.InducesdegradationofMcl-1;exhibitscomparablecytotoxicactivitytotaxol(Cat.No.1097)inepithelialovariancancercells.Activeinvivo.

TechnicalData

M.Wt	420.48
Formula	C₂₀H₂₂F₂N₄O₂S.CF₃CO₂H
Storage	Storeat-20°C
Purity	≥98%(HPLC)
CASNumber	885060-09-3
PubChemID	90488964
InChIKey	CIJUJPVFECBUKG-BDQAORGHSA-N
Smiles	FC1=CC=C(F)C=C1C2=NN(C(N(C)OC)=O)[C@](CCCN)([C@]3=CC=CC=C3)S2.FC(F)(F)C(O)=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	31.54	75
	ethanol	31.54	75

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight420.48.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.38mL	11.89mL	23.78mL
5mM	0.48mL	2.38mL	4.76mL
10mM	0.24mL	1.19mL	2.38mL
50mM	0.05mL	0.24mL	0.48mL

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