BiologicalActivity
PotentandselectiveATRkinaseinhibitor(IC50=5nM).Exhibits7.6-foldselectivityovermTORandselectivityoverapanelof442kinases,includingATMkinase,PI3-Kisoforms,andDNA-PK.Inhibitscellgrowthincelllineswithhighbaselinelevelsofreplicationstress.Displaysantitumoreffectsinvivo.
LicensingInformation
SoldforresearchpurposesunderagreementfromAstraZeneca
CompoundLibraries
AZ20isalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxII.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 412.51 |
| Formula | C21H24N4O3S |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 1233339-22-4 |
| PubChemID | 46244454 |
| InChIKey | SCGCBAAYLFTIJU-CQSZACIVSA-N |
| Smiles | CS(C4(CC4)C1=CC(N5[C@H](C)COCC5)=NC(C2=CC=CC3=C2C=CN3)=N1)(=O)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 20.63 | 50 | |
| ethanol | 4.13 | 10 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight412.51.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.42mL | 12.12mL | 24.24mL |
| 5mM | 0.48mL | 2.42mL | 4.85mL |
| 10mM | 0.24mL | 1.21mL | 2.42mL |
| 50mM | 0.05mL | 0.24mL | 0.48mL |
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