BiologicalActivity
Potentandselectivemonopolarspindle1(Mps1)kinaseinhibitor(IC50=35nM).Displaysselectivityover46otherkinasesincludingCdk1andaurorakinaseB.Interfereswithchromosomealignmentandoverridesspindleassemblycheckpoint.InhibitstherecruitmentofMad1,Mad2andcentromereproteinE(CENP-E)tokinetochores.
LicensingInformation
SoldforresearchpurposesonlyunderagreementfromAstraZenecaUKLtd.
CompoundLibraries
AZ3146isalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxI.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 452.55 |
| Formula | C24H32N6O3 |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 1124329-14-1 |
| PubChemID | 56973724 |
| InChIKey | YUKWVHPTFRQHMF-UHFFFAOYSA-N |
| Smiles | CN(C1=CN=C(NC4=CC=C(OC5CCN(C)CC5)C=C4OC)N=C1N2C3CCCC3)C2=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 11.31 | 25 | |
| ethanol | 33.94 | 75 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight452.55.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.21mL | 11.05mL | 22.1mL |
| 5mM | 0.44mL | 2.21mL | 4.42mL |
| 10mM | 0.22mL | 1.1mL | 2.21mL |
| 50mM | 0.04mL | 0.22mL | 0.44mL |
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