中国Tocris公司 Tocris化合物筛选文库,Tocris/AZ Dyrk1B 33/5632/10/10 mg,其它酶,酶,蛋白类,,Tocris Bioscience蚂蚁淘商城

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Tocris/AZ Dyrk1B 33/5632/10/10 mg

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Tocris

货号 /

5632/10

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4000-520-616

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Description:PotentandselectiveDyrk1Bkinaseinhibitor

ChemicalName:3-(2-Methyl-4-pyrimidinyl)-1-(phenylmethyl)-1H-pyrrolo[2,3-c]pyridine

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentandselectiveATP-competitiveDyrk1Bkinaseinhibitor(IC₅₀=7nM);displaysdistinctcellulareffectswhencomparedtoDYRK1BknockdownthroughsiRNA.Demonstratescellularinvitroactivity(IC₅₀=194nM).ExhibitsbetterselectivitythanAZ191(Cat.No5232);displaysnooff-targeteffectsagainstapanelof124kinasestested(nokinasewasinhibitedabove50%at1μM).

TechnicalData

M.Wt	300.36
Formula	C₁₉H₁₆N₄
Storage	Storeat+4°C
Purity	≥98%(HPLC)
CASNumber	1679330-37-0
PubChemID	118735338
InChIKey	CZCUSHJQJWKYTD-UHFFFAOYSA-N
Smiles	CC1=NC=CC(C2=CN(CC3=CC=CC=C3)C4=CN=CC=C42)=N1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	1eq.HCl	30.04	100
	DMSO	30.04	100
	ethanol	30.04	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight300.36.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	3.33mL	16.65mL	33.29mL
5mM	0.67mL	3.33mL	6.66mL
10mM	0.33mL	1.66mL	3.33mL
50mM	0.07mL	0.33mL	0.67mL

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