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Description:PotentandselectivePFKFB3inhibitor
ChemicalName:(2S)-N-[4-[[3-Cyano-1-[(3,5-dimethyl-4-isoxazolyl)methyl]-1H-indol-5-yl]oxy]phenyl]-2-pyrrolidinecarboxamide
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
PotentandselectivePFKFB3inhibitor(IC50valuesare11,159and1130nMforPFKFB3,PFKFB2andPFKFB1respectively).
TechnicalData
M.Wt | 455.51 |
Formula | C26H25N5O3 |
Storage | Storeat-20°C |
Purity | ≥98%(HPLC) |
CASNumber | 1704741-11-6 |
PubChemID | 91668554 |
InChIKey | NDIKFKQBWGMLCA-DEOSSOPVSA-N |
Smiles | N#CC1=CN(CC2=C(C)ON=C2C)C3=C1C=C(OC4=CC=C(NC([C@H]5NCCC5)=O)C=C4)C=C3 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 45.55 | 100 | |
ethanol | 45.55 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight455.51.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.2mL | 10.98mL | 21.95mL |
5mM | 0.44mL | 2.2mL | 4.39mL |
10mM | 0.22mL | 1.1mL | 2.2mL |
50mM | 0.04mL | 0.22mL | 0.44mL |
MolarityCalculator
MolarityCalculator
Calculatethemass,volume,orconcentrationrequiredforasolution.
ReconstitutionCalculator
ReconstitutionCalculator
DilutionCalculator
DilutionCalculator
Calculatethedilutionrequiredtoprepareastocksolution.
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet


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