- Description
- Additional
Description
Details
Description:Mouse monoclonal antibody to C-terminusof amyloid beta peptide 40 (Aβ40)
Purification:Protein G affinity purified
Product Type: Primary antibody-Detection antibody in matched antibody pair
Target Protein:C-terminus of amyloid beta peptide 40
Immunogen:KLH conjugated to a short peptide (GLMVGGVV) with amino acid sequence corresponding to the C-terminal of Aβ40
Fusion Myeloma:Sp2/0-Ag14
Specificity:This antibody recognizes the C-terminal sequence (GLMVGGVV) of Aβ40 and full length Aβ40.The antibody showed very weak to none cross-reactivity with Ab43 and Ab42.
Species Reacitvity:Humanand other primates; mouse, rat
Host / Isotype: Mouse, IgG1 Kappa
Formulation:Lyophilized from a solution in 0.01M PBS pH7.2
Reconstitution:Double distilled water is recommended to adjust the final concentration to 1.00mg/mL.
Storage: Store at -20oC
Research Area:Aging and neurodegenerative diseases
Background:
Aβ40 and Aβ42 are the two major amyloid peptides formed after cleavage of amyloid precursor protein. In blood and cerebrospinal fluid, the concentration of Aβ40 is about 10 timers higher than that of Aβ42. Aβ40 is the main component in the amyloid deposit of vascular amyloid angiopathy. Detection of Aβ40 is useful for the predication of Alzheimer’s disease. Lower than normal Aβ42/Aβ40 ratio in cerebrospinal fluid was found to be associated with increased risk of mild cognitive impairment and Alzheimer’s disease.
Application:
ELISA: In combination with capturer anti-amyloid peptide N-terminal antibody (mAb clone NT 5B8, Cat. No.: MO-M40094D), the antibody can detect Aβ40 in Sandwich ELISA assay.
References:
If research is published using this product, please inform Anogen in order to cite the reference on this datasheet. Anogen will provide one unit of product in the same category as gratitude.
Additional
Additional Information
| Product Specificity | mAb anti-Amyloid β Peptide 40, CV9 7B10, Detector |
|---|---|
| Application | EIA |
| Size | 0.1 mg |
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看有关产前诊断的一个资料，提到：“凡是酶活性能在成纤维细胞中表达均可用绒毛或羊水细胞的酶活性测定进行产前诊断，如溶酶体贮积症。”
不太理解，为什么成纤维细胞中表达的酶就能在绒毛或羊水细胞中测出来呢？绒毛的细胞跟成纤维细胞没什么直接关系吧？或者是因为成纤维细胞脱落到羊水中，破裂，然后就可以检测了？
求各位解答，谢谢。
