商品信息
联系客服
郑重提醒：
无质量问题不接受退换货，下单前请仔细核对信息。
下单后请及时联系客服核对商品价格，订单生效后再付款。
Boston Biochem/Torin 1/4247/10
免费咨询热线
4000-520-616
Biological Activity Technical DataAdditional InformationBackground Product DatasheetsCalculators
Biological Activity
Potent and selective mTOR inhibitor (IC50 = 2 - 10 nM for mTORC1 and mTORC2). Displays 200-fold selectivity for mTOR over DNA-PK, ATM and hVps34. Induces autophagy in HeLa cells.Technical Data
M.Wt:
607.62
Formula:
C35H28F3N5O2
Solubility:
Soluble to 1 mM in DMSO with gentle warming
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1222998-36-8
The technical data provided above is for guidance only.For batch specific data refer to the Certificate of Analysis.Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Licensing Caveats:
Sold under license from Whitehead Institute for Biomedical Research.
Background References
- An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1.Thoreen CC, Kang SA, Chang JW et al.J Biol Chem
- Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles.Galluzzi et al.Nat.Rev.Drug.Discov., 2017;
- The pharmacology of mTOR inhibition.Guertin and SabatiniSci.Signal., 2009;2:pe24
- Discovery of 1-(4(-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a highly potent, selective mammalian target of rapamycin (mTOR) inhibitor for the treatment of cancer.Liu et al.J.Med.Chem., 2010;53:7146
- mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway.Peterson et al.Cell., 2011;146:408
Product Datasheets
COA view current batch
or select another batch:
SDS
Reconstitution Calculator
Molarity Calculator
Reconstitution Calculator
Molarity Calculator
Citations for Torin 1
The citations listed below are publications that use Tocris products.Selected citations for Torin 1 include:
123Citations: Showing 1 - 10
- HIF1A and NFAT5 coordinate Na+-boosted antibacterial defense via enhanced autophagy and autolysosomal targeting.Authors: Neubert Et al.Autophagy2019;:1
- Lethal Poisoning of Cancer Cells by Respiratory Chain Inhibition plus Dimethyl α-Ketoglutarate.Authors: Sica Et al.Cell Rep2019;27:820
- Type 2 diabetes is associated with suppression of autophagy and lipid accumulation in β-cells.Authors: Ji Et al.J Cell Mol Med2019;23:2890
- Dysfunctional autophagy following exposure to pro-inflammatory cytokines contributes to pancreatic β-cell apoptosis.Authors: Lambelet Et al.Cell Death Dis2018;9:96
- Amino acids stimulate the endosome-to-Golgi trafficking through Ragulator and small GTPase Arl5.Authors: Shi Et al.Nat Commun2018;9:4987
- Is Ras a potential target in treatment against cutaneous squamous cell carcinoma?.Authors: Li Et al.J Cancer2018;9:3373
- mTOR-dependent phosphorylation controls TFEB nuclear export.Authors: Napolitano Et al.Nat Commun2018;9:3312
- Carbon monoxide-induced TFEB nuclear translocation enhances mitophagy/mitochondrial biogenesis in hepatocytes and ameliorates inflammatory liver injury.Authors: Kim Et al.Cell Death Dis2018;9:1060
- Phosphatidylinositol-5-Phosphate 4-Kinases Regulate Cellular Lipid Metabolism By Facilitating Autophagy.Authors: Lundquist Et al.Mol Cell2018;70:531
- PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells.Authors: Georgilis Et al.Cancer Cell2018;34:85
- Metabolic reprogramming of murine cardiomyocytes during autophagy requires the extracellular nutrient sensor decorin.Authors: Gubbiotti Et al.J Biol Chem2018;293:16940
- ULK1 O-GlcNAcylation Is Crucial for Activating VPS34 via ATG14L during Autophagy Initiation.Authors: Pyo Et al.Cell Rep2018;25:2878
- Autophagosomal YKT6 is required for fusion with lysosomes independently of syntaxin 17.Authors: Matsui Et al.J Cell Biol2018;217:2633
- Lysosomal Protein Lamtor1 Controls Innate Immune Responses via Nuclear Translocation of Transcription Factor EB.Authors: Hayama Et al.J Immunol2018;200:3790
- Integration of Distinct ShcA Signaling Complexes Promotes Breast Tumor Growth and Tyrosine Kinase Inhibitor Resistance.Authors: Ha Et al.Mol Cancer Res2018;16:894
- HEPES activates a MiT/TFE-dependent lysosomal-autophagic gene network in cultured cells: A call for caution.Authors: Tol Et al.Autophagy2018;14:437
- Role of the MAPK/cJun NH2-terminal kinase signaling pathway in starvation-induced autophagy.Authors: Barutcu Et al.Autophagy2018;14:1586
- Lifespan extension without fertility reduction following dietary addition of the autophagy activator Torin1 in Drosophila melanogaster.Authors: Mason Et al.PLoS One2018;13:e0190105
- Mapping the mammalian ribosome quality control complex interactome using proximity labeling approaches.Authors: Zuzow Et al.Mol Biol Cell2018;
- Tenovin-6 impairs autophagy by inhibiting autophagic flux.Authors: Yuan Et al.Cell Death Dis2017;8:e2608
- TBK1 Provides Context-Selective Support of the Activated AKT/mTOR Pathway in Lung Cancer.Authors: Cooper Et al.Cancer Res2017;77:5077
- Autophagosomal Content Profiling Reveals an LC3C-Dependent Piecemeal Mitophagy Pathway.Authors: Guerroue Et al.Mol Cell2017;68:786
- PARK2 Depletion Connects Energy and Oxidative Stress to PI3K/Akt Activation via PTEN S-Nitrosylation.Authors: Gupta Et al.Mol Cell2017;65:999
- Akt regulation of glycolysis mediates bioenergetic stability in epithelial cells.Authors: Hung Et al.Elife2017;6
- DGAT1-Dependent Lipid Droplet Biogenesis Protects Mitochondrial Function during Starvation-Induced Autophagy.Authors: Nguyen Et al.Dev Cell2017;42:9
- PtdIns3P controls mTORC1 signaling through lysosomal positioning.Authors: Hong Et al.J Cell Biol2017;216:4217
- Tim-3 is a Marker of Plasmacytoid Dendritic Cell Dysfunction during HIV Infection and Is Associated with the Recruitment of IRF7 and p85 into Lysosomes and with the Submembrane Displacement of TLR9.Authors: Schwartz Et al.J Immunol2017;198:3181
- TORC1 and TORC2 converge to regulate the SAGA co-activator in response to nutrient availability.Authors: Laboucarié Et al.EMBO Rep2017;18:2197
- Deubiquitinase OTUD6B Isoforms Are Important Regulators of Growth and Proliferation.Authors: Sobol Et al.Mol Cancer Res2017;15:117
- The E3 ubiquitin ligase NEDD4 enhances killing of membrane-perturbing intracellular bacteria by promoting autophagy.Authors: Pei Et al.Autophagy2017;13:2041
- Loss of ULK1 increases RPS6KB1-NCOR1 repression of NR1H/LXR-mediated Scd1 transcription and augments lipotoxicity in hepatic cells.Authors: Sinha Et al.Autophagy2017;13:169
- The anti-tumor drug 2-hydroxyoleic acid (Minerval) stimulates signaling and retrograde transport.Authors: Torgersen Et al.Oncotarget2016;7:86871
- TSC loss distorts DNA replication programme and sensitises cells to genotoxic stress.Authors: Pai Et al.Oncotarget2016;7:85365
- Diagnostic and clinical relevance of the autophago-lysosomal network in human gliomas.Authors: Jennewein Et al.Oncotarget2016;7:20016
- Polarization of M2 macrophages requires Lamtor1 that integrates cytokine and amino-acid signalsAuthors: Kimura Et al.Nature Communications2016;7:13130
- mTORC1 and CK2 coordinate ternary and eIF4F complex assembly.Authors: Gandin Et al.Nat Commun2016;7:11127
- mTORC1-mediated inhibition of polycystin-1 expression drives renal cyst formation in tuberous sclerosis complex.Authors: Pema Et al.Mol Biol Cell2016;7:10786
- Trehalose, sucrose and raffinose are novel activators of autophagy in human keratinocytes through an mTOR-independent pathway.Authors: Chen Et al.PLoS One2016;6:28423
- LKB1 loss links serine metabolism to DNA methylation and tumorigenesis.Authors: Kottakis Et al.Nature2016;539:390
- An evolutionarily conserved mechanism for cAMP elicited axonal regeneration involves direct activation of the dual leucine zipper kinase DLK.Authors: Hao Et al.Proc Natl Acad Sci U S A2016;5
- Characterizing inactive ribosomes in translational profiling.Authors: LiuTranslation (Austin)2016;4:e1138018
- Oncogenic PI3K and K-Ras stimulate de novo lipid synthesis through mTORC1 and SREBP.Authors: Ricoult Et al.Oncogene2016;35:1250
- TDP-43 loss of function increases TFEB activity and blocks autophagosome-lysosome fusion.Authors: Xia Et al.EMBO J2016;35:121
- A novel Rab10-EHBP1-EHD2 complex essential for the autophagic engulfment of lipid droplets.Authors: Li Et al.Sci Adv2016;2:e1601470
- Nutrient-regulated Phosphorylation of ATG13 Inhibits Starvation-induced Autophagy.Authors: Puente Et al.J Biol Chem2016;291:6026
- RACK1 Is an Interaction Partner of ATG5 and a Novel Regulator of Autophagy.Authors: Erbil Et al.J Biol Chem2016;291:16753
- mTOR controls lysosome tubulation and antigen presentation in macrophages and dendritic cells.Authors: Saric Et al.Autophagy2016;27:321
- nanoCAGE reveals 5' UTR features that define specific modes of translation of functionally related MTOR-sensitive mRNAs.Authors: Gandin Et al.Genome Res2016;26:636
- Involvement of PARK2-Mediated Mitophagy in Idiopathic Pulmonary Fibrosis Pathogenesis.Authors: Kobayashi Et al.J Immunol2016;197:504
- Neuronal gene repression in Niemann-Pick type C models is mediated by the c-Abl/HDAC2 signaling pathway.Authors: Contreras Et al.Biochim Biophys Acta2016;1859:269
- A Founder Mutation in VPS11 Causes an Autosomal Recessive Leukoencephalopathy Linked to Autophagic Defects.Authors: Zhang Et al.Cell Rep2016;12:e1005848
- Drosophila Mitf regulates the V-ATPase and the lysosomal-autophagic pathway.Authors: Bouche Et al.Autophagy2016;12:484
- Hypoxia promotes noncanonical autophagy in nucleus pulposus cells independent of MTOR and HIF1A signaling.Authors: Choi Et al.Autophagy2016;12:1631
- Iron overload causes endolysosomal deficits modulated by NAADP-regulated 2-pore channels and RAB7A.Authors: Fernández Et al.Autophagy2016;12:1487
- TFEB and TFE3 cooperate in the regulation of the innate immune response in activated macrophages.Authors: Pastore Et al.Autophagy2016;12:1240
- TP53INP2/DOR, a mediator of cell autophagy, promotes rDNA transcription via facilitating the assembly of the POLR1/RNA polymerase I preinitiation complex at rDNA promoters.Authors: Xu Et al.Autophagy2016;12:1118
- IL-15 activates mTOR and primes stress-activated gene expression leading to prolonged antitumor capacity of NK cells.Authors: Mao Et al.Blood2016;128:1475
- IBMPFD Disease-Causing Mutant VCP/p97 Proteins Are Targets of Autophagic-Lysosomal Degradation.Authors: Bayraktar Et al.PLoS One2016;11:e0164864
- The Loss of Lam2 and Npr2-Npr3 Diminishes the Vacuolar Localization of Gtr1-Gtr2 and Disinhibits TORC1 Activity in Fission Yeast.Authors: Ma Et al.PLoS One2016;11:e0156239
- Trehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency: a novel therapeutic lead to treat frontotemporal dementia.Authors: Holler Et al.Mol Neurodegener2016;11:46
- Activation of 5-HT7 receptor stimulates neurite elongation through mTOR, Cdc42 and actin filaments dynamics.Authors: Speranza Et al.Nat Chem Biol2015;9:62
- The MAPK and PI3K pathways mediate CNTF-induced neuronal survival and process outgrowth in hypothalamic organotypic cultures.Authors: Askvig and WattJ Cell Commun Signal2015;9:217
- The mTORC1/4E-BP pathway coordinates hemoglobin production with L-leucine availability.Authors: Chung Et al.Mol Cancer Res2015;8:ra34
- Autophagy restricts HIV-1 infection by selectively degrading Tat in CD4+ T lymphocytes.Authors: Sagnier Et al.J Virol2015;89:615
- Reinstating aberrant mTORC1 activity in Huntington's disease mice improves disease phenotypes.Authors: Lee Et al.Neuron2015;85:303
- Autophagy regulates hepatocyte identity and epithelial-to-mesenchymal and mesenchymal-to-epithelial transitions promoting Snail degradation.Authors: Grassi Et al.Cell Death Dis2015;6:e1880
- Regulation of autophagy by coordinated action of mTORC1 and protein phosphatase 2A.Authors: Wong Et al.Nat Commun2015;6:8048
- Autophagy activation and protection from mitochondrial dysfunction in human chondrocytes.Authors: Figueroa Et al.Autophagy2015;67:966
- SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1.Authors: Rebsamen Et al.Autophagy2015;519:477
- Diacylglycerol kinase-ζ regulates mTORC1 and lipogenic metabolism in cancer cells through SREBP-1.Authors: Torres-Ayuso Et al.Oncogenesis2015;4:e164
- Decorin is an autophagy-inducible proteoglycan and is required for proper in vivo autophagy.Authors: Gubbiotti Et al.Matrix Biol2015;48:14
- Regulation of the transcription factor EB-PGC1α axis by beclin-1 controls mitochondrial quality and cardiomyocyte death under stress.Authors: Ma Et al.Mol Cell Biol2015;35:956
- Amino Acid-Dependent mTORC1 Regulation by the Lysosomal Membrane Protein SLC38A9.Authors: Jung Et al.Mol Cell Biol2015;35:2479
- HIV-1 Tat alters neuronal autophagy by modulating autophagosome fusion to the lysosome: implications for HIV-associated neurocognitive disorders.Authors: Fields Et al.J Neurosci2015;35:1921
- La-related Protein 1 (LARP1) Represses Terminal Oligopyrimidine (TOP) mRNA Translation Downstream of mTOR Complex 1 (mTORC1).Authors: Fonseca Et al.J Biol Chem2015;290:15996
- Cholesterol-mediated activation of acid sphingomyelinase disrupts autophagy in the retinal pigment epithelium.Authors: Toops Et al.J Exp Med2015;26:41640
- Amyloid precursor protein (APP) affects global protein synthesis in dividing human cells.Authors: Sobol Et al.J Cell Physiol2015;230:1064
- PDK1 orchestrates early NK cell development through induction of E4BP4 expression and maintenance of IL-15 responsiveness.Authors: Yang Et al.J Clin Invest2015;212:253
- Apoptotic effects of high-dose rapamycin occur in S-phase of the cell cycle.Authors: Saqcena Et al.Autophagy2015;14:2285
- A mechanism for asymmetric cell division resulting in proliferative asynchronicity.Authors: Dey-Guha Et al.Autophagy2015;13:223
- mTORC1-Induced HK1-Dependent Glycolysis Regulates NLRP3 Inflammasome Activation.Authors: Moon Et al.Cell Rep2015;12:102
- Coactivator SRC-2-dependent metabolic reprogramming mediates prostate cancer survival and metastasis.Authors: Dasgupta Et al.Sci Signal2015;125:1174
- Phosphoproteomic Analysis of KSHV-Infected Cells Reveals Roles of ORF45-Activated RSK during Lytic Replication.Authors: Avey Et al.PLoS Pathog2015;11:e1004993
- GSK-3 modulates cellular responses to a broad spectrum of kinase inhibitors.Authors: Thorne Et al.Mol Biol Cell2015;11:58
- PARK2-mediated mitophagy is involved in regulation of HBEC senescence in COPD pathogenesis.Authors: Ito Et al.Nature2015;11:547
- Pharmacological inhibition of lysosomes activates the MTORC1 signaling pathway in chondrocytes in an autophagy-independent manner.Authors: Newton Et al.Autophagy2015;11:1594
- mTORC2 regulates cardiac response to stress by inhibiting MST1.Authors: Sciarretta Et al.Elife2015;11:125
- TNFAIP3 promotes survival of CD4 T cells by restricting MTOR and promoting autophagy.Authors: Matsuzawa Et al.Sci Rep2015;11:1052
- Hedgehog signaling activates a positive feedback mechanism involving Ins-like growth factors to induce osteoblast differentiation.Authors: Shi Et al.Front Behav Neurosci2015;112:4678
- Tor Signaling Regulates Transcription of Amino Acid Permeases through a GATA Transcription Factor Gaf1 in Fission Yeast.Authors: Ma Et al.PLoS One2015;10:e0144677
- Rapamycin-insensitive up-regulation of adipocyte phospholipase A2 in tuberous sclerosis and lymphangioleiomyomatosis.Authors: Li Et al.J Exp Med2014;9:e104809
- Fertilization-induced autophagy in mouse embryos is independent of mTORC1.Authors: Yamamoto Et al.Biol Reprod2014;91:7
- The nutrient-responsive transcription factor TFE3 promotes autophagy, lysosomal biogenesis, and clearance of cellular debris.Authors: Martina Et al.Sci Signal2014;7:ra9
- Oncogenic mutations in adenomatous polyposis coli (Apc) activate mechanistic target of rapamycin complex 1 (mTORC1) in mice and zebrafish.Authors: Valvezan Et al.Dis Model Mech2014;7:63
- Palmitate induces mRNA translation and increases ER protein load in islet β-cells via activation of the mammalian target of rapamycin pathway.Authors: Hatanaka Et al.Diabetes2014;63:3404
- Regulation of YAP by mTOR and autophagy reveals a therapeutic target of tuberous sclerosis complex.Authors: Liang Et al.J Exp Med2014;211:2249
- OE and mTORC2 cooperate to enhance prostaglandin biosynthesis and tumorigenesis in TSC2-deficient LAM cells.Authors: Li Et al.BMC Biochem2014;211:15
- Mammalian target of Rapamycin inhibition and mycobacterial survival are uncoupled in murine macrophages.Authors: Zullo Et al.Proc Natl Acad Sci U S A2014;15:4
- An invertebrate Warburg effect: a shrimp virus achieves successful replication by altering the host metabolome via the PI3K-Akt-mTOR pathway.Authors: Su Et al.PLoS Pathog2014;10:e1004196
- Development of a novel method for quantification of autophagic protein degradation by AHA labeling.Authors: Zhang Et al.PLoS Genet2014;10:901
- Expression of the autophagy substrate SQSTM1/p62 is restored during prolonged starvation depending on transcriptional upregulation and autophagy-derived amino acids.Authors: Sahani Et al.Autophagy2014;10:431
- Autophagy fosters myofibroblast differentiation through MTORC2 activation and downstream upregulation of CTGF.Authors: Bernard Et al.Cell Cycle2014;10:2193
- Japanese encephalitis virus replication is negatively regulated by autophagy and occurs on LC3-I- and EDEM1-containing membranes.Authors: Sharma Et al.Arthritis Rheumatol2014;10:1637
- p53-directed translational control can shape and expand the universe of p53 target genes.Authors: Zaccara Et al.Cell Death Differ2014;
- Live imaging and single-cell analysis reveal differential dynamics of autophagy and apoptosis.Authors: Xu Et al.Autophagy2013;9:1418
- ATP-competitive mTOR kinase inhibitors delay plant growth by triggering early differentiation of meristematic cells but no developmental patterning change.Authors: Montané and MenandNat Commun2013;64:4361
- Stimulation of autophagy improves endoplasmic reticulum stress-induced diabetes.Authors: Bachar-Wikstrom Et al.Diabetes2013;62:1227
- Differential regulation of the expressions of the PGC-1α splice variants, lipins, and PPARα in heart compared to liver.Authors: Kok Et al.J Lipid Res2013;54:1662
- Selective targeting of human colon cancer stem-like cells by the mTOR inhibitor Torin-1.Authors: Francipane and LagasseOncotarget2013;4:1948
- Epigenetic regulation of autophagy by the methyltransferase G9a.Authors: Narvajas Et al.Mol Cell Biol2013;33:3983
- Inactivation of the mTORC1-eukaryotic translation initiation factor 4E pathway alters stress granule formation.Authors: Fournier Et al.Mol Cell Biol2013;33:2285
- Suppression of lysosome function induces autophagy via a feedback down-regulation of MTOR complex 1 (MTORC1) activity.Authors: Li Et al.J Biol Chem2013;288:35769
- mTOR complex 2 phosphorylates IMP1 cotranslationally to promote IGF2 production and the proliferation of mouse embryonic fibroblasts.Authors: Dai Et al.Genes Dev2013;27:301
- SYK regulates mTOR signaling in AML.Authors: Carnevale Et al.Leukemia2013;27:2118
- mTOR regulates phagosome and entotic vacuole fission.Authors: Krajcovic Et al.Mol Biol Cell2013;24:3736
- Activation of lysosomal function in the course of autophagy via mTORC1 suppression and autophagosome-lysosome fusion.Authors: Zhou Et al.Cell Res2013;23:508
- Interaction between FIP200 and ATG16L1 distinguishes ULK1 complex-dependent and -independent autophagy.Authors: Gammoh Et al.Nat Struct Mol Biol2013;20:144
- Rag GTPases mediate amino acid-dependent recruitment of TFEB and MITF to lysosomes.Authors: Martina and PuertollanoJ Cell Biol2013;200:475
- mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation.Authors: Morita Et al.Cell Metab2013;18:698
- WNT-LRP5 signaling induces Warburg effect through mTORC2 activation during osteoblast differentiation.Authors: Esen Et al.Cell Metab2013;17:745
- MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB.Authors: Martina Et al.Autophagy2012;8:903
- Structure-activity analysis of niclosamide reveals potential role for cytoplasmic pH in control of mammalian target of rapamycin complex 1 (mTORC1) signaling.Authors: Fonseca Et al.J Biol Chem2012;287:17530
- Keap1 degradation by autophagy for the maintenance of redox homeostasis.Authors: Taguchi Et al.J Exp Bot2012;109:13561
FAQs
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQsReviews for Torin 1
Average Rating: 5(Based on 2 Reviews)
Have you used Torin 1?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Filter by:
We got expected effect on cells
By Anonymouson 04/03/2020
Application: Species:Mouse
0.076–500 nM Torin
inhibition of Torin in acute brain slices
By Anonymouson 01/10/2018
Application: Species:Mouse
We used Torin-1 to inhibit torin signalling, we got the expected effect on metabolic changes in acute brain slices
蚂蚁淘电商平台
ebiomall.com
ebiomall.com
公司简介
蚂蚁淘（www.ebiomall.cn）是中国大陆目前唯一的生物医疗科研用品B2B跨境交易平台，
该平台由多位经验丰富的生物人和IT人负责运营。蚂蚁淘B2B模式是指客户有采购意向后在蚂蚁
淘搜索全球供应信息，找到合适的产品后在蚂蚁淘下单，然后蚂蚁淘的海外买手进行跨境采购、
运输到中国口岸，最后由蚂蚁淘国内团队报关运输给客户...
蚂蚁淘承诺
正品保证： 全球直采 在线追溯
蚂蚁淘所有产品都是自运营的，我们已经跟国外多家厂方建立品牌推广合作关系, 获得对方的支持和授权； 同时客户可以通过订单详情查看到货物从厂方至客户的所有流程， 确保货物的来源； 正规报关，提供13%增值税发票。
及时交付： 限时必达 畅选无忧
蚂蚁淘的运营团队都是有着多年经验的成员，他们熟悉海外采购、仓储物流、报关等环节； 同时通过在线的流程监控，蚂蚁淘的进口速度比传统企业提高了50%以上， 部分产品甚至能做到7-10天到货，即蚂蚁淘的“时必达”服务。
轻松采购： 在线下单 简单省事
蚂蚁淘的价格是真实透明的，并且具有很大的价格优势，不需要繁杂的询价比价； 报价单与合同可以直接在线生成或打印；就像在京东购物一样， 您的鼠标点击几 次即完成在蚂蚁淘的采购，订单详情会告诉您所有进程。
售后申请： 耐心讲解 优质服务
蚂蚁淘提供的产品在使用过程中如因产品质量问题有售后需求时， 您可通过我的订单提交您的“申请售后”， 蚂蚁淘产品顾问会第一时间为您处理， 在售后服务过程中如遇到问题也可致电蚂蚁淘客服热线：4000-520-616。
上海研生实业有限公司所提供的P27抗体,周期素依赖激酶抑制剂抗体质量可靠、规格齐全,上海研生实业有限公司不仅具有精湛的技术水平,更有良好的售后服务和优质的解决方案,欢迎您来电咨询此产品具体参数及价格等详细信息！ 查看更多
>
Nature Chemical Biology：一种可助治疗老年痴呆症的酶抑制剂，加拿大研究人员研究发现使用一种酶抑制剂可阻止tau蛋白中糖类的去除，或可有利于老年痴呆症的治疗。这项发现为我们对老年痴呆症的内在研究提供了新见解。该研究发表于本月出版的《自然—化学生物学》上。老年痴呆症的症状表现为失忆和精神错乱。从细胞层面上来看，该病的特点则是tau蛋白不断累积，直至形成较大纤维。许多研究老年痴呆症的科学家往往试图找到能直接与这些纤维进行反应的分子，分解或者阻碍纤维的形成，从而治疗此病。不过， ... 查看更多
>
2021-08-03
1. 焦磷酸二乙酯（DEPC）：是一种强烈但不彻底的RNA酶抑制剂。它通过和RNA酶的活性基团组氨酸的咪唑环结合使蛋白质变性，从而抑制酶的活性。 2. 异硫氰酸胍：目前被认为是最有效的RNA酶抑制剂，它在裂解组织的同时也使RNA酶失活。它既可破坏细胞结构使核酸从核蛋白中解离出来，又对RNA酶有强烈的变性作用。 3. 氧钒核糖核苷复合物：由氧化钒离子和核苷形成的复合物，它和RNA酶结合形成过渡态类物质，几乎能完全抑制RNA酶的活性。 4.... 查看更多
>
2019-03-06
Caspase 激活的脱氧核糖核酸酶抑制剂（抗原）现货直销，快递发货，含票含运费，提供说明书,欢迎来电咨询. 查看更多
>
2021-09-23
血管紧张素转化酶抑制剂(ACEI)是一种抑制血管紧张素转化酶活性的化合物。血管紧张素转化酶催化血管紧张素I生成血管紧张素II，后者是强烈的血管收缩剂和肾上腺皮质类醛固酮释放的激活剂。... 查看更多
>
2018-06-01
EGFR（表皮生长因子受体）的小分子抑制剂已被广泛应用于肺癌治疗中。一小部分（3-13%）的非小细胞肺癌（NSCLC）已经被证明在ALK（间变性淋巴瘤激酶）基因中有重新排列。在过去的几年中，ALK抑制剂与传统的化疗相比，对ALK-阳性NSCLC的管理有显著益处。 查看更多
>
2018-12-26
@font-face{font-family:"Times New Roman";}@font-face{font-family:"宋体";}@font-face{font-family:"Arial Narrow";}@font-face{font-family:"Symbol";}@font-face{font- 查看更多
>
2019-03-06
人血管活性肽酶抑制剂(VPI)ELISA试剂盒现货直销，快递发货，提供一对一的技术服务和免费代测服务 查看更多
>
2018-12-25
v:* {behavior:url(#default#VML);}o:* {behavior:url(#default#VML);}w:* {behavior:url(#default#VML);}.shape {behavior:url(# 查看更多
>
2019-01-26
广州柏赛柯生物技术有限公司在发布的Pepstatin(天冬氨酸蛋白酶抑制剂)26305-03-3供应信息，浏览与Pepstatin(天冬氨酸蛋白酶抑制剂)26305-03-3相关的产品或在搜索更多与Pepstatin(天冬氨酸蛋白酶抑制剂)26305-03-3相关的内容。 查看更多
>
常见问题
蚂蚁淘所售产品均为正品吗？
蚂蚁淘的创始人兼CEO是钟定松先生，具有十年的从业经验，在业界享有良好的口碑；
Ebiomall是跨境直采平台，我们直接从厂家采购，自己的团队负责国际物流和清关，中间没有第三方，蚂蚁淘承诺所售产品仅为正品，假一罚十。
下单后可以修改订单吗？
未确认状态的订单可以修改，打开“订单详情”页面，点击右上角的“修改订单”即可，若已审核确定，则订单无法修改。
商品几天可以发货？
现货产品付款审核后即可发货,大部分期货产品在3周左右即可到货,提供时必达服务的产品订单审核十天内即可发货。
订单如何取消？
如订单处于未确定状态，进入“我的订单"页面，找到要取消的订单，点击“取消订单”按钮。
可以开发票吗？
本网站所售商品都是正规清关，均开具13%正规发票，发票金额含配送费金额，另有说明的除外。
如何联系商家？
蚂蚁淘任何页面都有在线咨询功能，点击“联系客服”、“咨询”或“在线咨询”按钮，均可咨询蚂蚁淘在线客服人员，
或拨打4000-520-616，除此之外客户可在 联系我们页面找到更多的联系方式。
收到的商品少了/发错了怎么办？
同个订单购买多个商品可能会分为一个以上包裹发出，可能不会同时送达，建议查看订单详情是否是部分发货状态；如未收到，可联系在线客服或者致电4000-520-616。
退换货/维修需要多长时间？
一般情况下，退货处理周期为客户收到产品一个月内（以快递公司显示签收时间为准），包装规格、数量、品种不符，外观毁损、短缺或缺陷，请在收到货24小时内申请退换货；特殊商品以合同条款为准。
商品咨询
《血管紧张素转换酶抑制剂在心血管病中应用的中国专家共识》解读123
axe20092010-07-25
相关疾病：高血压慢性心力衰竭冠心病心肌梗死糖尿病1977年施贵宝公司科学家ondetti等根据血管紧张素转换酶底物的化学结构推测设计出ACE的活性部位模型，1981年全球第一个血管紧张素转换酶抑制剂类药物卡托普利上市并用于治疗高血压，被列入降压药物......
《血管紧张素转换酶抑制剂在心血管病中应用的中国专家共识》.PDF(242.69k)
《血管紧张素转换酶抑制剂在心血管病中应用的中国专家共识》.PDF(242.69k)
【求助】酶抑制剂的活性测定 形态学与生理生化讨论版论坛123
gaalaa2009-02-13
以前生化方面的实验接触很少，最近做一个酶抑制剂筛选工作，酶活性通过生成物吸光度测定。查了一些文献，发现酶的用量和底物用量文献之间差别很大，我想问一下
1.对于抑制剂筛选工作（求ic50）是不是体系内酶与底物的量（底物应该是过量的）对实验结果影响不大。
2.如果要求算Km值，是不是需要知道反应产物的绝对量。反应时间文献上都是5分钟，反应速度就用反应产物量除以反应时间即可。
3.酶是进口分装的，规格5U，一次用不完，用PBS稀释后如何保存
谢谢
1.对于抑制剂筛选工作（求ic50）是不是体系内酶与底物的量（底物应该是过量的）对实验结果影响不大。
2.如果要求算Km值，是不是需要知道反应产物的绝对量。反应时间文献上都是5分钟，反应速度就用反应产物量除以反应时间即可。
3.酶是进口分装的，规格5U，一次用不完，用PBS稀释后如何保存
谢谢
酶的抑制剂类型及各种抑制剂的特点是什么?_123
9565195152018-01-28
1、不可逆抑制剂：如烷化剂、有机磷、重金属盐、氰化物等
2、可逆抑制剂：包括
a、竞争性抑制剂，抑制剂与底物竞争性结合酶反应中心，使Km增大，而Vmax不变 b、非竞争性抑制剂，酶与抑制剂结合后还能与底物结合，但活性降低，使Vmax减小，而Km不变
c、反竞争性抑制剂，酶只能与底物结合后才能与抑制剂结合，Vmax与Km都减小
可逆抑制剂可用透析等方法除去，使酶恢复作用
2、可逆抑制剂：包括
a、竞争性抑制剂，抑制剂与底物竞争性结合酶反应中心，使Km增大，而Vmax不变 b、非竞争性抑制剂，酶与抑制剂结合后还能与底物结合，但活性降低，使Vmax减小，而Km不变
c、反竞争性抑制剂，酶只能与底物结合后才能与抑制剂结合，Vmax与Km都减小
可逆抑制剂可用透析等方法除去，使酶恢复作用
伤胃习惯排行榜专家支招让胃更健康 123
ucyz2592018-02-23
（血管紧张素转换酶抑制剂）包括卡托普利，贝那普利，依那普利，培哚普利等；（血管紧张素Ⅱ受体拮抗剂）包括缬沙坦，氯沙坦，厄贝沙坦，坎地沙坦等。这两类药物除了降压的作用外还可保护肾功能消减尿蛋白，但是ACEI（血管紧张素转换酶抑制剂）主要的副作用是咳嗽和血管性水肿，此时可以换副作用相对较少的ARB（血管紧张素Ⅱ受体拮抗剂）。
高等药物化学酶抑制剂课件.ppt123
zrj2004-07-12
酪氨酸酶抑制剂快速筛选方法的建立 中国知网 123
zjs123092012-04-06
本人最近在做中药里酪氨酸酶抑制剂的筛选，存在一些疑惑，望大家帮忙解答。
1、测定酶比活力：底物需要过量么？测定时间多长？是否可以加入过量的底物，然后测定3min吸光度的增加值，从吸光度的变化值计算比活力。
2、在酶抑制剂筛选的过程中，是否需要保证底物过量？还是要水浴一定时间让反应完全？我看到文献说用终浓度为0.1μmol/mL的底物，终浓度为45U/ml的酶，我想问，假设总体积为1ml，那么终浓度为45U/ml的酶岂不是每分钟能转化4.8μmol的底物？那么0.1μmol/mL的底物不就几秒钟就反应完了？那么怎么测定初速度？
1、测定酶比活力：底物需要过量么？测定时间多长？是否可以加入过量的底物，然后测定3min吸光度的增加值，从吸光度的变化值计算比活力。
2、在酶抑制剂筛选的过程中，是否需要保证底物过量？还是要水浴一定时间让反应完全？我看到文献说用终浓度为0.1μmol/mL的底物，终浓度为45U/ml的酶，我想问，假设总体积为1ml，那么终浓度为45U/ml的酶岂不是每分钟能转化4.8μmol的底物？那么0.1μmol/mL的底物不就几秒钟就反应完了？那么怎么测定初速度？
组蛋白去乙酰化酶抑制剂有效对抗卵巢癌细胞123
lmx980062021-07-20
相关疾病：卵巢癌癌症研究人员报告，组蛋白去乙酰化酶抑制剂（HDACIs），包括丙戊酸和SAHA，有效地抑制了人类卵巢癌细胞的增生，并诱发了凋亡。&n......
▍
品牌分类
▍
官网分类
▍
品牌问答
